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Management of Vernal Keratoconjunctivitis
Vernal keratoconjunctivitis (VKC) is a relatively rare, chronic form of ocular allergy that can potentially cause severe visual complications. Affecting mainly children and young adults, it is an IgE- and T cell-mediated disease, leading to a chronic inflammation in which eosinophil, lymphocyte and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108143/ https://www.ncbi.nlm.nih.gov/pubmed/25135808 http://dx.doi.org/10.1007/s40123-013-0019-y |
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author | Leonardi, Andrea |
author_facet | Leonardi, Andrea |
author_sort | Leonardi, Andrea |
collection | PubMed |
description | Vernal keratoconjunctivitis (VKC) is a relatively rare, chronic form of ocular allergy that can potentially cause severe visual complications. Affecting mainly children and young adults, it is an IgE- and T cell-mediated disease, leading to a chronic inflammation in which eosinophil, lymphocyte and structural cell activation are involved. Treatment of VKC requires a multiple approach that includes conservative measures and pharmacologic treatment. Patients and parents should be made aware of the long duration of disease, its chronic evolution and possible complications. Treatment should be based on the duration and frequency of symptoms and the severity of corneal involvement. Mast cell stabilizers and antihistamines have been proven to be effective for the treatment of mild to moderate forms of VKC. In the most severe cases, topical steroids can be used as rescue medication to reduce conjunctival and corneal inflammation. Immunomodulators that have been investigated for VKC treatment include topical ocular preparations of cyclosporine A and tacrolimus. Topical cyclosporine A has been proven to be effective in the long-term treatment of VKC, significantly improving signs and symptoms without significant side effects. |
format | Online Article Text |
id | pubmed-4108143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-41081432014-07-24 Management of Vernal Keratoconjunctivitis Leonardi, Andrea Ophthalmol Ther Review Vernal keratoconjunctivitis (VKC) is a relatively rare, chronic form of ocular allergy that can potentially cause severe visual complications. Affecting mainly children and young adults, it is an IgE- and T cell-mediated disease, leading to a chronic inflammation in which eosinophil, lymphocyte and structural cell activation are involved. Treatment of VKC requires a multiple approach that includes conservative measures and pharmacologic treatment. Patients and parents should be made aware of the long duration of disease, its chronic evolution and possible complications. Treatment should be based on the duration and frequency of symptoms and the severity of corneal involvement. Mast cell stabilizers and antihistamines have been proven to be effective for the treatment of mild to moderate forms of VKC. In the most severe cases, topical steroids can be used as rescue medication to reduce conjunctival and corneal inflammation. Immunomodulators that have been investigated for VKC treatment include topical ocular preparations of cyclosporine A and tacrolimus. Topical cyclosporine A has been proven to be effective in the long-term treatment of VKC, significantly improving signs and symptoms without significant side effects. Springer Healthcare 2013-09-07 2013-12 /pmc/articles/PMC4108143/ /pubmed/25135808 http://dx.doi.org/10.1007/s40123-013-0019-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Leonardi, Andrea Management of Vernal Keratoconjunctivitis |
title | Management of Vernal Keratoconjunctivitis |
title_full | Management of Vernal Keratoconjunctivitis |
title_fullStr | Management of Vernal Keratoconjunctivitis |
title_full_unstemmed | Management of Vernal Keratoconjunctivitis |
title_short | Management of Vernal Keratoconjunctivitis |
title_sort | management of vernal keratoconjunctivitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108143/ https://www.ncbi.nlm.nih.gov/pubmed/25135808 http://dx.doi.org/10.1007/s40123-013-0019-y |
work_keys_str_mv | AT leonardiandrea managementofvernalkeratoconjunctivitis |