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Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases

[Image: see text] Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two analogues generated through...

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Detalles Bibliográficos
Autores principales:	Gable, Jonathan E., Lee, Gregory M., Jaishankar, Priyadarshini, Hearn, Brian R., Waddling, Christopher A., Renslo, Adam R., Craik, Charles S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108181/ https://www.ncbi.nlm.nih.gov/pubmed/24977643 http://dx.doi.org/10.1021/bi5003234

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