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Application of high-strength biodegradable polyurethanes containing different ratios of biobased isomannide and poly (ϵ-caprolactone) diol
Biodegradable–biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(ϵ-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by (1)H-nuclear magnetic resonance, Fouri...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108296/ https://www.ncbi.nlm.nih.gov/pubmed/25076809 http://dx.doi.org/10.1177/0883911513484572 |
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author | Lim, Dong-In Park, Hyung-Seok Park, Jeong-Hui Knowles, Jonathan C Gong, Myoung-Seon |
author_facet | Lim, Dong-In Park, Hyung-Seok Park, Jeong-Hui Knowles, Jonathan C Gong, Myoung-Seon |
author_sort | Lim, Dong-In |
collection | PubMed |
description | Biodegradable–biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(ϵ-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by (1)H-nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The glass transition temperatures were determined by thermal analysis to be between 25°C and 30°C. Degradation tests performed at 37°C in phosphate buffer produced mass losses of 5%–10% after 8 weeks. After 5 days of culture, using osteoblastic cells, the relative cell number on all the polyurethane films was only slightly lower than that of an optimized tissue culture plastic. These polymers offer significant promise with a simplistic synthesis and controlled degradation. |
format | Online Article Text |
id | pubmed-4108296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-41082962014-07-28 Application of high-strength biodegradable polyurethanes containing different ratios of biobased isomannide and poly (ϵ-caprolactone) diol Lim, Dong-In Park, Hyung-Seok Park, Jeong-Hui Knowles, Jonathan C Gong, Myoung-Seon J Bioact Compat Polym Articles Biodegradable–biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(ϵ-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by (1)H-nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The glass transition temperatures were determined by thermal analysis to be between 25°C and 30°C. Degradation tests performed at 37°C in phosphate buffer produced mass losses of 5%–10% after 8 weeks. After 5 days of culture, using osteoblastic cells, the relative cell number on all the polyurethane films was only slightly lower than that of an optimized tissue culture plastic. These polymers offer significant promise with a simplistic synthesis and controlled degradation. SAGE Publications 2013-05 /pmc/articles/PMC4108296/ /pubmed/25076809 http://dx.doi.org/10.1177/0883911513484572 Text en © The Author(s) 2013 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Articles Lim, Dong-In Park, Hyung-Seok Park, Jeong-Hui Knowles, Jonathan C Gong, Myoung-Seon Application of high-strength biodegradable polyurethanes containing different ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
title | Application of high-strength biodegradable polyurethanes containing different
ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
title_full | Application of high-strength biodegradable polyurethanes containing different
ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
title_fullStr | Application of high-strength biodegradable polyurethanes containing different
ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
title_full_unstemmed | Application of high-strength biodegradable polyurethanes containing different
ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
title_short | Application of high-strength biodegradable polyurethanes containing different
ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
title_sort | application of high-strength biodegradable polyurethanes containing different
ratios of biobased isomannide and poly (ϵ-caprolactone) diol |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108296/ https://www.ncbi.nlm.nih.gov/pubmed/25076809 http://dx.doi.org/10.1177/0883911513484572 |
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