Cargando…
White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes
The phenotypes of the behavioral variant of frontotemporal dementia and the corticobasal syndrome present considerable clinical and anatomical overlap. The respective patterns of white matter damage in these syndromes have not been directly contrasted. Beyond cortical involvement, damage to white ma...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108323/ https://www.ncbi.nlm.nih.gov/pubmed/25054218 http://dx.doi.org/10.1371/journal.pone.0102656 |
_version_ | 1782327737443155968 |
---|---|
author | Tovar-Moll, Fernanda de Oliveira-Souza, Ricardo Bramati, Ivanei Edson Zahn, Roland Cavanagh, Alyson Tierney, Michael Moll, Jorge Grafman, Jordan |
author_facet | Tovar-Moll, Fernanda de Oliveira-Souza, Ricardo Bramati, Ivanei Edson Zahn, Roland Cavanagh, Alyson Tierney, Michael Moll, Jorge Grafman, Jordan |
author_sort | Tovar-Moll, Fernanda |
collection | PubMed |
description | The phenotypes of the behavioral variant of frontotemporal dementia and the corticobasal syndrome present considerable clinical and anatomical overlap. The respective patterns of white matter damage in these syndromes have not been directly contrasted. Beyond cortical involvement, damage to white matter pathways may critically contribute to both common and specific symptoms in both conditions. Here we assessed patients with the behavioral variant of frontotemporal dementia and corticobasal syndrome with whole-brain diffusion tensor imaging to identify the white matter networks underlying these pathologies. Twenty patients with the behavioral variant of frontotemporal dementia, 19 with corticobasal syndrome, and 15 healthy controls were enrolled in the study. Differences in tract integrity between (i) patients and controls, and (ii) patients with the corticobasal syndrome and the behavioral variant of frontotemporal dementia were assessed with whole brain tract-based spatial statistics and analyses of regions of interest. Behavioral variant of frontotemporal dementia and the corticobasal syndrome shared a pattern of bilaterally decreased white matter integrity in the anterior commissure, genu and body of the corpus callosum, corona radiata and in the long intrahemispheric association pathways. Patients with the behavioral variant of frontotemporal dementia showed greater damage to the uncinate fasciculus, genu of corpus callosum and forceps minor. In contrast, corticobasal syndrome patients had greater damage to the midbody of the corpus callosum and perirolandic corona radiata. Whereas several compact white matter pathways were damaged in both the behavioral variant of frontotemporal dementia and corticobasal syndrome, the distribution and degree of white matter damage differed between them. These findings concur with the distinctive clinical manifestations of these conditions and may improve the in vivo neuroanatomical and diagnostic characterization of these disorders. |
format | Online Article Text |
id | pubmed-4108323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41083232014-07-24 White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes Tovar-Moll, Fernanda de Oliveira-Souza, Ricardo Bramati, Ivanei Edson Zahn, Roland Cavanagh, Alyson Tierney, Michael Moll, Jorge Grafman, Jordan PLoS One Research Article The phenotypes of the behavioral variant of frontotemporal dementia and the corticobasal syndrome present considerable clinical and anatomical overlap. The respective patterns of white matter damage in these syndromes have not been directly contrasted. Beyond cortical involvement, damage to white matter pathways may critically contribute to both common and specific symptoms in both conditions. Here we assessed patients with the behavioral variant of frontotemporal dementia and corticobasal syndrome with whole-brain diffusion tensor imaging to identify the white matter networks underlying these pathologies. Twenty patients with the behavioral variant of frontotemporal dementia, 19 with corticobasal syndrome, and 15 healthy controls were enrolled in the study. Differences in tract integrity between (i) patients and controls, and (ii) patients with the corticobasal syndrome and the behavioral variant of frontotemporal dementia were assessed with whole brain tract-based spatial statistics and analyses of regions of interest. Behavioral variant of frontotemporal dementia and the corticobasal syndrome shared a pattern of bilaterally decreased white matter integrity in the anterior commissure, genu and body of the corpus callosum, corona radiata and in the long intrahemispheric association pathways. Patients with the behavioral variant of frontotemporal dementia showed greater damage to the uncinate fasciculus, genu of corpus callosum and forceps minor. In contrast, corticobasal syndrome patients had greater damage to the midbody of the corpus callosum and perirolandic corona radiata. Whereas several compact white matter pathways were damaged in both the behavioral variant of frontotemporal dementia and corticobasal syndrome, the distribution and degree of white matter damage differed between them. These findings concur with the distinctive clinical manifestations of these conditions and may improve the in vivo neuroanatomical and diagnostic characterization of these disorders. Public Library of Science 2014-07-23 /pmc/articles/PMC4108323/ /pubmed/25054218 http://dx.doi.org/10.1371/journal.pone.0102656 Text en © 2014 Tovar-Moll et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Tovar-Moll, Fernanda de Oliveira-Souza, Ricardo Bramati, Ivanei Edson Zahn, Roland Cavanagh, Alyson Tierney, Michael Moll, Jorge Grafman, Jordan White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes |
title | White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes |
title_full | White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes |
title_fullStr | White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes |
title_full_unstemmed | White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes |
title_short | White Matter Tract Damage in the Behavioral Variant of Frontotemporal and Corticobasal Dementia Syndromes |
title_sort | white matter tract damage in the behavioral variant of frontotemporal and corticobasal dementia syndromes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108323/ https://www.ncbi.nlm.nih.gov/pubmed/25054218 http://dx.doi.org/10.1371/journal.pone.0102656 |
work_keys_str_mv | AT tovarmollfernanda whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT deoliveirasouzaricardo whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT bramatiivaneiedson whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT zahnroland whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT cavanaghalyson whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT tierneymichael whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT molljorge whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes AT grafmanjordan whitemattertractdamageinthebehavioralvariantoffrontotemporalandcorticobasaldementiasyndromes |