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Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1(G93A) Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice

Dominant mutations in the Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons. The molecular mechanism underlying the toxic gain-of-function of mutant hSOD1s remains uncertain. Several...

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Detalles Bibliográficos
Autores principales:	Pehar, Mariana, Beeson, Gyda, Beeson, Craig C., Johnson, Jeffrey A., Vargas, Marcelo R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108402/ https://www.ncbi.nlm.nih.gov/pubmed/25054289 http://dx.doi.org/10.1371/journal.pone.0103438

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