Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion

Recent evidence suggests that host immune cells contribute to the development of malignant pleural effusion (MPE), a common manifestation of metastatic cancer. We have identified such cells, predominantly mononuclear myeloid cells, recruited by tumor-orchestrated inflammatory chemokines. Moreover, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Marazioti, Antonia, Stathopoulos, Georgios T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108461/
https://www.ncbi.nlm.nih.gov/pubmed/25083335
http://dx.doi.org/10.4161/onci.29195
_version_ 1782327762125586432
author Marazioti, Antonia
Stathopoulos, Georgios T
author_facet Marazioti, Antonia
Stathopoulos, Georgios T
author_sort Marazioti, Antonia
collection PubMed
description Recent evidence suggests that host immune cells contribute to the development of malignant pleural effusion (MPE), a common manifestation of metastatic cancer. We have identified such cells, predominantly mononuclear myeloid cells, recruited by tumor-orchestrated inflammatory chemokines. Moreover, targeting of these inflammation-associated mediators modified the disease course of MPE in mice.
format Online
Article
Text
id pubmed-4108461
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-41084612014-07-31 Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion Marazioti, Antonia Stathopoulos, Georgios T Oncoimmunology Author's View Recent evidence suggests that host immune cells contribute to the development of malignant pleural effusion (MPE), a common manifestation of metastatic cancer. We have identified such cells, predominantly mononuclear myeloid cells, recruited by tumor-orchestrated inflammatory chemokines. Moreover, targeting of these inflammation-associated mediators modified the disease course of MPE in mice. Landes Bioscience 2014-06-11 /pmc/articles/PMC4108461/ /pubmed/25083335 http://dx.doi.org/10.4161/onci.29195 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Marazioti, Antonia
Stathopoulos, Georgios T
Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
title Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
title_full Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
title_fullStr Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
title_full_unstemmed Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
title_short Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
title_sort monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108461/
https://www.ncbi.nlm.nih.gov/pubmed/25083335
http://dx.doi.org/10.4161/onci.29195
work_keys_str_mv AT maraziotiantonia monoclonalantibodytargetingofmononuclearcellchemokinesdrivingmalignantpleuraleffusion
AT stathopoulosgeorgiost monoclonalantibodytargetingofmononuclearcellchemokinesdrivingmalignantpleuraleffusion

Ejemplares similares