Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment

Glioblastoma multiforme (GBM) has a very poor prognosis, despite multimodal therapy including surgery, radiation and chemotherapy. A novel adoptive immunotherapy that exploits the presence of cytomegalovirus antigens in malignant brain cancer cells has been shown to be safe and elicit potential clin...

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Detalles Bibliográficos
Autores principales: Schuessler, Andrea, Walker, David G, Khanna, Rajiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108464/
https://www.ncbi.nlm.nih.gov/pubmed/25083342
http://dx.doi.org/10.4161/onci.29381
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author Schuessler, Andrea
Walker, David G
Khanna, Rajiv
author_facet Schuessler, Andrea
Walker, David G
Khanna, Rajiv
author_sort Schuessler, Andrea
collection PubMed
description Glioblastoma multiforme (GBM) has a very poor prognosis, despite multimodal therapy including surgery, radiation and chemotherapy. A novel adoptive immunotherapy that exploits the presence of cytomegalovirus antigens in malignant brain cancer cells has been shown to be safe and elicit potential clinical benefit for the treatment of recurrent GBM.
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spelling pubmed-41084642014-07-31 Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment Schuessler, Andrea Walker, David G Khanna, Rajiv Oncoimmunology Author's View Glioblastoma multiforme (GBM) has a very poor prognosis, despite multimodal therapy including surgery, radiation and chemotherapy. A novel adoptive immunotherapy that exploits the presence of cytomegalovirus antigens in malignant brain cancer cells has been shown to be safe and elicit potential clinical benefit for the treatment of recurrent GBM. Landes Bioscience 2014-06-25 /pmc/articles/PMC4108464/ /pubmed/25083342 http://dx.doi.org/10.4161/onci.29381 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Schuessler, Andrea
Walker, David G
Khanna, Rajiv
Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
title Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
title_full Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
title_fullStr Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
title_full_unstemmed Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
title_short Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
title_sort cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108464/
https://www.ncbi.nlm.nih.gov/pubmed/25083342
http://dx.doi.org/10.4161/onci.29381
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