Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury

Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantatio...

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Detalles Bibliográficos
Autores principales: ODA, Yasutaka, TANI, Kenji, ASARI, Yusuke, QUINTANILHA, Luiz Fernando, HARAGUCHI, Tomoya, MOMOTA, Yutaka, KATAYAMA, Masaaki, ITAMOTO, Kazuhito, NAKAZAWA, Hiroshi, TAURA, Yasuho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108777/
https://www.ncbi.nlm.nih.gov/pubmed/24561315
http://dx.doi.org/10.1292/jvms.13-0587
Descripción
Sumario:Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs. These results suggest that canine BMSCs promote functional recovery in mice with SCI and that migration of nestin-positive cells may contribute to the efficacy of the BMSC treatment.

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