Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury

Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantatio...

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Autores principales: ODA, Yasutaka, TANI, Kenji, ASARI, Yusuke, QUINTANILHA, Luiz Fernando, HARAGUCHI, Tomoya, MOMOTA, Yutaka, KATAYAMA, Masaaki, ITAMOTO, Kazuhito, NAKAZAWA, Hiroshi, TAURA, Yasuho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108777/
https://www.ncbi.nlm.nih.gov/pubmed/24561315
http://dx.doi.org/10.1292/jvms.13-0587
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author ODA, Yasutaka
TANI, Kenji
ASARI, Yusuke
QUINTANILHA, Luiz Fernando
HARAGUCHI, Tomoya
MOMOTA, Yutaka
KATAYAMA, Masaaki
ITAMOTO, Kazuhito
NAKAZAWA, Hiroshi
TAURA, Yasuho
author_facet ODA, Yasutaka
TANI, Kenji
ASARI, Yusuke
QUINTANILHA, Luiz Fernando
HARAGUCHI, Tomoya
MOMOTA, Yutaka
KATAYAMA, Masaaki
ITAMOTO, Kazuhito
NAKAZAWA, Hiroshi
TAURA, Yasuho
author_sort ODA, Yasutaka
collection PubMed
description Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs. These results suggest that canine BMSCs promote functional recovery in mice with SCI and that migration of nestin-positive cells may contribute to the efficacy of the BMSC treatment.
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spelling pubmed-41087772014-07-24 Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury ODA, Yasutaka TANI, Kenji ASARI, Yusuke QUINTANILHA, Luiz Fernando HARAGUCHI, Tomoya MOMOTA, Yutaka KATAYAMA, Masaaki ITAMOTO, Kazuhito NAKAZAWA, Hiroshi TAURA, Yasuho J Vet Med Sci Surgery Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs. These results suggest that canine BMSCs promote functional recovery in mice with SCI and that migration of nestin-positive cells may contribute to the efficacy of the BMSC treatment. The Japanese Society of Veterinary Science 2014-02-21 2014-06 /pmc/articles/PMC4108777/ /pubmed/24561315 http://dx.doi.org/10.1292/jvms.13-0587 Text en ©2014 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Surgery
ODA, Yasutaka
TANI, Kenji
ASARI, Yusuke
QUINTANILHA, Luiz Fernando
HARAGUCHI, Tomoya
MOMOTA, Yutaka
KATAYAMA, Masaaki
ITAMOTO, Kazuhito
NAKAZAWA, Hiroshi
TAURA, Yasuho
Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
title Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
title_full Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
title_fullStr Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
title_full_unstemmed Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
title_short Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
title_sort canine bone marrow stromal cells promote functional recovery in mice with spinal cord injury
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108777/
https://www.ncbi.nlm.nih.gov/pubmed/24561315
http://dx.doi.org/10.1292/jvms.13-0587
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