Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Hedgehog signaling drives oncogenesis in several cancers and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened. However, resistance to Smoothened inhibitors occurs via genetic changes of Smoothened or other downstream Hedgehog components. Here, we o...

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Detalles Bibliográficos
Autores principales: Tang, Yujie, Gholamin, Sharareh, Schubert, Simone, Willardson, Minde I., Lee, Alex, Bandopadhayay, Pratiti, Bergthold, Guillame, Masoud, Sabran, Nguyen, Brian, Vue, Nujsaubnusi, Balansay, Brianna, Yu, Furong, Oh, Sekyung, Woo, Pamelyn, Chen, Spenser, Ponnuswami, Anitha, Monje, Michelle, Atwood, Scott X., Whitson, Ramon J., Mitra, Siddhartha, Cheshier, Samuel H., Qi, Jun, Beroukhim, Rameen, Tang, Jean Y., Wechsler-Reya, Rob, Oro, Anthony E., Link, Brian A., Bradner, James E., Cho, Yoon-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108909/
https://www.ncbi.nlm.nih.gov/pubmed/24973920
http://dx.doi.org/10.1038/nm.3613

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