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Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines

BACKGROUND: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. METHODS: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in...

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Autores principales: El Baroudi, Mariama, La Sala, Dario, Cinti, Caterina, Capobianco, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108926/
https://www.ncbi.nlm.nih.gov/pubmed/25077705
http://dx.doi.org/10.1186/1742-4682-11-S1-S8
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author El Baroudi, Mariama
La Sala, Dario
Cinti, Caterina
Capobianco, Enrico
author_facet El Baroudi, Mariama
La Sala, Dario
Cinti, Caterina
Capobianco, Enrico
author_sort El Baroudi, Mariama
collection PubMed
description BACKGROUND: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. METHODS: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors. RESULTS: Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them.
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spelling pubmed-41089262014-08-04 Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines El Baroudi, Mariama La Sala, Dario Cinti, Caterina Capobianco, Enrico Theor Biol Med Model Research BACKGROUND: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. METHODS: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors. RESULTS: Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them. BioMed Central 2014-05-07 /pmc/articles/PMC4108926/ /pubmed/25077705 http://dx.doi.org/10.1186/1742-4682-11-S1-S8 Text en Copyright © 2014 Baroudi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
El Baroudi, Mariama
La Sala, Dario
Cinti, Caterina
Capobianco, Enrico
Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
title Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
title_full Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
title_fullStr Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
title_full_unstemmed Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
title_short Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
title_sort pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108926/
https://www.ncbi.nlm.nih.gov/pubmed/25077705
http://dx.doi.org/10.1186/1742-4682-11-S1-S8
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