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Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
BACKGROUND: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. METHODS: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108926/ https://www.ncbi.nlm.nih.gov/pubmed/25077705 http://dx.doi.org/10.1186/1742-4682-11-S1-S8 |
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author | El Baroudi, Mariama La Sala, Dario Cinti, Caterina Capobianco, Enrico |
author_facet | El Baroudi, Mariama La Sala, Dario Cinti, Caterina Capobianco, Enrico |
author_sort | El Baroudi, Mariama |
collection | PubMed |
description | BACKGROUND: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. METHODS: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors. RESULTS: Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them. |
format | Online Article Text |
id | pubmed-4108926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41089262014-08-04 Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines El Baroudi, Mariama La Sala, Dario Cinti, Caterina Capobianco, Enrico Theor Biol Med Model Research BACKGROUND: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. METHODS: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors. RESULTS: Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them. BioMed Central 2014-05-07 /pmc/articles/PMC4108926/ /pubmed/25077705 http://dx.doi.org/10.1186/1742-4682-11-S1-S8 Text en Copyright © 2014 Baroudi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research El Baroudi, Mariama La Sala, Dario Cinti, Caterina Capobianco, Enrico Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
title | Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
title_full | Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
title_fullStr | Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
title_full_unstemmed | Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
title_short | Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
title_sort | pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108926/ https://www.ncbi.nlm.nih.gov/pubmed/25077705 http://dx.doi.org/10.1186/1742-4682-11-S1-S8 |
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