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Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells
Down’s syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactiv...
Autores principales: | Chen, Chen, Jiang, Peng, Xue, Haipeng, Peterson, Suzanne E., Tran, Ha T., McCann, Anna E., Parast, Mana M., Li, Shenglan, Pleasure, David E., Laurent, Louise C., Loring, Jeanne F., Liu, Ying, Deng, Wenbin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109022/ https://www.ncbi.nlm.nih.gov/pubmed/25034944 http://dx.doi.org/10.1038/ncomms5430 |
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