Cargando…

Identification of platelet function defects by multi-parameter assessment of thrombus formation

Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from healthy subjects and patients with platelet fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Witt, Susanne M., Swieringa, Frauke, Cavill, Rachel, Lamers, Moniek M. E., van Kruchten, Roger, Mastenbroek, Tom, Baaten, Constance, Coort, Susan, Pugh, Nicholas, Schulz, Ansgar, Scharrer, Inge, Jurk, Kerstin, Zieger, Barbara, Clemetson, Kenneth J., Farndale, Richard W., Heemskerk, Johan W. M., Cosemans, Judith M.E.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109023/ https://www.ncbi.nlm.nih.gov/pubmed/25027852 http://dx.doi.org/10.1038/ncomms5257

Ejemplares similares

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies
por: Nagy, Magdolna, et al.
Publicado: (2018)

Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation
por: Brouns, Sanne L. N., et al.
Publicado: (2020)

High-throughput elucidation of thrombus formation reveals sources of platelet function variability
por: van Geffen, Johanna P., et al.
Publicado: (2019)

Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions
por: Huang, Jingnan, et al.
Publicado: (2021)

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome
por: Solari, Fiorella A., et al.
Publicado: (2016)

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome
por: van Geffen, Johanna P., et al.
Publicado: (2020)

Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability
por: Zou, Jinmi, et al.
Publicado: (2022)

Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis
por: Provenzale, Isabella, et al.
Publicado: (2019)

Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation
por: Hall, Kellie J., et al.
Publicado: (2008)

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces
por: Jooss, Natalie J., et al.
Publicado: (2019)

Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
por: Wu, Jiayu, et al.
Publicado: (2021)

Integrating platelet and coagulation activation in fibrin clot formation
por: Swieringa, Frauke, et al.
Publicado: (2018)

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis
por: Govers-Riemslag, José W. P., et al.
Publicado: (2019)

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis
por: Nagy, Magdolna, et al.
Publicado: (2019)

MMP‐13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation
por: Howes, Joanna‐Marie, et al.
Publicado: (2018)

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function
por: Tullemans, Bibian M.E., et al.
Publicado: (2021)

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy
por: Baaten, Constance C. F. M. J., et al.
Publicado: (2018)

Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro
por: Brinkman, Herm Jan M., et al.
Publicado: (2022)

Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow
por: Schönichen, Claudia, et al.
Publicado: (2023)

Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques
por: Nergiz-Unal, Reyhan, et al.
Publicado: (2010)

Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS
por: Swieringa, Frauke, et al.
Publicado: (2020)

Combined Antiplatelet Therapy Reduces the Proinflammatory Properties of Activated Platelets
por: Heinzmann, Alexandra C.A., et al.
Publicado: (2021)

Key role of integrin α(IIb)β(3) signaling to Syk kinase in tissue factor-induced thrombin generation
por: van der Meijden, Paola E. J., et al.
Publicado: (2012)

Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation
por: Kuijpers, Marijke J. E., et al.
Publicado: (2022)

Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation
por: Navarro, Stefano, et al.
Publicado: (2021)

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I
por: Howes, J.‐M., et al.
Publicado: (2015)

Effects of Platelet Agonists and Priming on the Formation of Platelet Populations
por: Veninga, Alicia, et al.
Publicado: (2021)

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation
por: Induruwa, I., et al.
Publicado: (2018)

Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear
por: Perrella, Gina, et al.
Publicado: (2022)

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan
por: Provenzale, Isabella, et al.
Publicado: (2023)

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1
por: De Simone, Ilaria, et al.
Publicado: (2022)

CKD Effects on Platelets: Implications for Cardiovascular Risk
por: Baaten, Constance C.F.M.J., et al.
Publicado: (2022)

Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease
por: Baaten, Constance C.F.M.J., et al.
Publicado: (2023)

An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts
por: Tantiwong, Chukiat, et al.
Publicado: (2023)

Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review
por: Harlacher, Eva, et al.
Publicado: (2022)

Dynamic analysis of platelet deposition to resolve platelet adhesion receptor activity in whole blood at arterial shear rate
por: Pugh, Nicholas, et al.
Publicado: (2015)

Toward Zero Variance in Proteomics Sample Preparation: Positive-Pressure FASP in 96-Well Format (PF96) Enables Highly Reproducible, Time- and Cost-Efficient Analysis of Sample Cohorts
por: Loroch, Stefan, et al.
Publicado: (2022)

Molecular Proteomics and Signalling of Human Platelets in Health and Disease
por: Huang, Jingnan, et al.
Publicado: (2021)

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation
por: Jooss, Natalie J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ofvl85vskl3kcao6c6bib5vibr