Metabolic heterogeneity of obesity: role of adipose tissue

Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat an...

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Detalles Bibliográficos
Autor principal: McLaughlin, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Proceedings Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109083/
https://www.ncbi.nlm.nih.gov/pubmed/25089194
http://dx.doi.org/10.1038/ijosup.2012.3
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author McLaughlin, T
author_facet McLaughlin, T
author_sort McLaughlin, T
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description Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.
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spelling pubmed-41090832014-07-31 Metabolic heterogeneity of obesity: role of adipose tissue McLaughlin, T Int J Obes Suppl Proceedings Article Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance. Nature Publishing Group 2012-07 2012-07-10 /pmc/articles/PMC4109083/ /pubmed/25089194 http://dx.doi.org/10.1038/ijosup.2012.3 Text en Copyright © 2012 Macmillan Publishers Limited
spellingShingle Proceedings Article
McLaughlin, T
Metabolic heterogeneity of obesity: role of adipose tissue
title Metabolic heterogeneity of obesity: role of adipose tissue
title_full Metabolic heterogeneity of obesity: role of adipose tissue
title_fullStr Metabolic heterogeneity of obesity: role of adipose tissue
title_full_unstemmed Metabolic heterogeneity of obesity: role of adipose tissue
title_short Metabolic heterogeneity of obesity: role of adipose tissue
title_sort metabolic heterogeneity of obesity: role of adipose tissue
topic Proceedings Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109083/
https://www.ncbi.nlm.nih.gov/pubmed/25089194
http://dx.doi.org/10.1038/ijosup.2012.3
work_keys_str_mv AT mclaughlint metabolicheterogeneityofobesityroleofadiposetissue

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