Cargando…

Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models

Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-...

Descripción completa

Detalles Bibliográficos
Autores principales: Queiroz, João Carlos C., Antoniolli, Ângelo R., Quintans-Júnior, Lucindo J., Brito, Renan G., Barreto, Rosana S. S., Costa, Emmanoel V., da Silva, Thanany B., Prata, Ana Paula Nascimento, de Lucca, Waldecy, Almeida, Jackson R. G. S., Lima, Julianeli T., Quintans, Jullyana S. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109226/
https://www.ncbi.nlm.nih.gov/pubmed/25097889
http://dx.doi.org/10.1155/2014/816450
_version_ 1782327852894519296
author Queiroz, João Carlos C.
Antoniolli, Ângelo R.
Quintans-Júnior, Lucindo J.
Brito, Renan G.
Barreto, Rosana S. S.
Costa, Emmanoel V.
da Silva, Thanany B.
Prata, Ana Paula Nascimento
de Lucca, Waldecy
Almeida, Jackson R. G. S.
Lima, Julianeli T.
Quintans, Jullyana S. S.
author_facet Queiroz, João Carlos C.
Antoniolli, Ângelo R.
Quintans-Júnior, Lucindo J.
Brito, Renan G.
Barreto, Rosana S. S.
Costa, Emmanoel V.
da Silva, Thanany B.
Prata, Ana Paula Nascimento
de Lucca, Waldecy
Almeida, Jackson R. G. S.
Lima, Julianeli T.
Quintans, Jullyana S. S.
author_sort Queiroz, João Carlos C.
collection PubMed
description Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.
format Online
Article
Text
id pubmed-4109226
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41092262014-08-05 Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models Queiroz, João Carlos C. Antoniolli, Ângelo R. Quintans-Júnior, Lucindo J. Brito, Renan G. Barreto, Rosana S. S. Costa, Emmanoel V. da Silva, Thanany B. Prata, Ana Paula Nascimento de Lucca, Waldecy Almeida, Jackson R. G. S. Lima, Julianeli T. Quintans, Jullyana S. S. ScientificWorldJournal Research Article Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders. Hindawi Publishing Corporation 2014 2014-07-03 /pmc/articles/PMC4109226/ /pubmed/25097889 http://dx.doi.org/10.1155/2014/816450 Text en Copyright © 2014 João Carlos C. Queiroz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Queiroz, João Carlos C.
Antoniolli, Ângelo R.
Quintans-Júnior, Lucindo J.
Brito, Renan G.
Barreto, Rosana S. S.
Costa, Emmanoel V.
da Silva, Thanany B.
Prata, Ana Paula Nascimento
de Lucca, Waldecy
Almeida, Jackson R. G. S.
Lima, Julianeli T.
Quintans, Jullyana S. S.
Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_full Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_fullStr Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_full_unstemmed Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_short Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_sort evaluation of the anti-inflammatory and antinociceptive effects of the essential oil from leaves of xylopia laevigata in experimental models
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109226/
https://www.ncbi.nlm.nih.gov/pubmed/25097889
http://dx.doi.org/10.1155/2014/816450
work_keys_str_mv AT queirozjoaocarlosc evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT antoniolliangelor evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT quintansjuniorlucindoj evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT britorenang evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT barretorosanass evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT costaemmanoelv evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT dasilvathananyb evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT prataanapaulanascimento evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT deluccawaldecy evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT almeidajacksonrgs evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT limajulianelit evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels
AT quintansjullyanass evaluationoftheantiinflammatoryandantinociceptiveeffectsoftheessentialoilfromleavesofxylopialaevigatainexperimentalmodels