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Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109226/ https://www.ncbi.nlm.nih.gov/pubmed/25097889 http://dx.doi.org/10.1155/2014/816450 |
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author | Queiroz, João Carlos C. Antoniolli, Ângelo R. Quintans-Júnior, Lucindo J. Brito, Renan G. Barreto, Rosana S. S. Costa, Emmanoel V. da Silva, Thanany B. Prata, Ana Paula Nascimento de Lucca, Waldecy Almeida, Jackson R. G. S. Lima, Julianeli T. Quintans, Jullyana S. S. |
author_facet | Queiroz, João Carlos C. Antoniolli, Ângelo R. Quintans-Júnior, Lucindo J. Brito, Renan G. Barreto, Rosana S. S. Costa, Emmanoel V. da Silva, Thanany B. Prata, Ana Paula Nascimento de Lucca, Waldecy Almeida, Jackson R. G. S. Lima, Julianeli T. Quintans, Jullyana S. S. |
author_sort | Queiroz, João Carlos C. |
collection | PubMed |
description | Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders. |
format | Online Article Text |
id | pubmed-4109226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41092262014-08-05 Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models Queiroz, João Carlos C. Antoniolli, Ângelo R. Quintans-Júnior, Lucindo J. Brito, Renan G. Barreto, Rosana S. S. Costa, Emmanoel V. da Silva, Thanany B. Prata, Ana Paula Nascimento de Lucca, Waldecy Almeida, Jackson R. G. S. Lima, Julianeli T. Quintans, Jullyana S. S. ScientificWorldJournal Research Article Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders. Hindawi Publishing Corporation 2014 2014-07-03 /pmc/articles/PMC4109226/ /pubmed/25097889 http://dx.doi.org/10.1155/2014/816450 Text en Copyright © 2014 João Carlos C. Queiroz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Queiroz, João Carlos C. Antoniolli, Ângelo R. Quintans-Júnior, Lucindo J. Brito, Renan G. Barreto, Rosana S. S. Costa, Emmanoel V. da Silva, Thanany B. Prata, Ana Paula Nascimento de Lucca, Waldecy Almeida, Jackson R. G. S. Lima, Julianeli T. Quintans, Jullyana S. S. Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
title | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
title_full | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
title_fullStr | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
title_full_unstemmed | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
title_short | Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models |
title_sort | evaluation of the anti-inflammatory and antinociceptive effects of the essential oil from leaves of xylopia laevigata in experimental models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109226/ https://www.ncbi.nlm.nih.gov/pubmed/25097889 http://dx.doi.org/10.1155/2014/816450 |
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