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An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH produced a difference in specificity exceeding 12...

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Detalles Bibliográficos
Autores principales:	Boucher, Jeffrey I, Jacobowitz, Joseph R, Beckett, Brian C, Classen, Scott, Theobald, Douglas L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109310/ https://www.ncbi.nlm.nih.gov/pubmed/24966208 http://dx.doi.org/10.7554/eLife.02304

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