Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells

Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of HIV-1 viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein gp120, are poor...

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Detalles Bibliográficos
Autores principales: Yu, Xinwei, Feizpour, Amin, Ramirez, Nora-Guadalupe P., Wu, Linxi, Akiyama, Hisashi, Xu, Fangda, Gummuluru, Suryaram, Reinhard, Björn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109413/
https://www.ncbi.nlm.nih.gov/pubmed/24947940
http://dx.doi.org/10.1038/ncomms5136

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