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New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases

Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defin...

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Autores principales: Nigro, Ersilia, Scudiero, Olga, Monaco, Maria Ludovica, Palmieri, Alessia, Mazzarella, Gennaro, Costagliola, Ciro, Bianco, Andrea, Daniele, Aurora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109424/
https://www.ncbi.nlm.nih.gov/pubmed/25110685
http://dx.doi.org/10.1155/2014/658913
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author Nigro, Ersilia
Scudiero, Olga
Monaco, Maria Ludovica
Palmieri, Alessia
Mazzarella, Gennaro
Costagliola, Ciro
Bianco, Andrea
Daniele, Aurora
author_facet Nigro, Ersilia
Scudiero, Olga
Monaco, Maria Ludovica
Palmieri, Alessia
Mazzarella, Gennaro
Costagliola, Ciro
Bianco, Andrea
Daniele, Aurora
author_sort Nigro, Ersilia
collection PubMed
description Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defined “adipocytokines,” protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth. In obesity, fat accumulation causes dysregulation of adipokine production that strongly contributes to the onset of obesity-related diseases. Several advances have been made in the treatment and prevention of obesity but current medical therapies are often unsuccessful even in compliant patients. Among the adipokines, adiponectin shows protective activity in various processes such as energy metabolism, inflammation, and cell proliferation. In this review, we will focus on the current knowledge regarding the protective properties of adiponectin and its receptors, AdipoRs (“adiponectin system”), on metabolic complications in obesity and obesity-related diseases. Adiponectin, exhibiting antihyperglycemic, antiatherogenic, and anti-inflammatory properties, could have important clinical benefits in terms of development of therapies for the prevention and/or for the treatment of obesity and obesity-related diseases.
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spelling pubmed-41094242014-08-10 New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases Nigro, Ersilia Scudiero, Olga Monaco, Maria Ludovica Palmieri, Alessia Mazzarella, Gennaro Costagliola, Ciro Bianco, Andrea Daniele, Aurora Biomed Res Int Review Article Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defined “adipocytokines,” protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth. In obesity, fat accumulation causes dysregulation of adipokine production that strongly contributes to the onset of obesity-related diseases. Several advances have been made in the treatment and prevention of obesity but current medical therapies are often unsuccessful even in compliant patients. Among the adipokines, adiponectin shows protective activity in various processes such as energy metabolism, inflammation, and cell proliferation. In this review, we will focus on the current knowledge regarding the protective properties of adiponectin and its receptors, AdipoRs (“adiponectin system”), on metabolic complications in obesity and obesity-related diseases. Adiponectin, exhibiting antihyperglycemic, antiatherogenic, and anti-inflammatory properties, could have important clinical benefits in terms of development of therapies for the prevention and/or for the treatment of obesity and obesity-related diseases. Hindawi Publishing Corporation 2014 2014-07-07 /pmc/articles/PMC4109424/ /pubmed/25110685 http://dx.doi.org/10.1155/2014/658913 Text en Copyright © 2014 Ersilia Nigro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nigro, Ersilia
Scudiero, Olga
Monaco, Maria Ludovica
Palmieri, Alessia
Mazzarella, Gennaro
Costagliola, Ciro
Bianco, Andrea
Daniele, Aurora
New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
title New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
title_full New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
title_fullStr New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
title_full_unstemmed New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
title_short New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
title_sort new insight into adiponectin role in obesity and obesity-related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109424/
https://www.ncbi.nlm.nih.gov/pubmed/25110685
http://dx.doi.org/10.1155/2014/658913
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