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Target identification strategies in plant chemical biology

The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies. Gene redundancy and lethality can substantially complicate research, which might be solved by applying a chemical genetics approach. Now...

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Detalles Bibliográficos
Autores principales: Dejonghe, Wim, Russinova, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109434/
https://www.ncbi.nlm.nih.gov/pubmed/25104953
http://dx.doi.org/10.3389/fpls.2014.00352
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author Dejonghe, Wim
Russinova, Eugenia
author_facet Dejonghe, Wim
Russinova, Eugenia
author_sort Dejonghe, Wim
collection PubMed
description The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies. Gene redundancy and lethality can substantially complicate research, which might be solved by applying a chemical genetics approach. Now understood as the study of small molecules and their effect on biological systems with subsequent target identification, chemical genetics is a fast developing field with a strong history in pharmaceutical research and drug discovery. In plant biology however, chemical genetics is still largely in the starting blocks, with most studies relying on forward genetics and phenotypic analysis for target identification, whereas studies including direct target identification are limited. Here, we provide an overview of recent advances in chemical genetics in plant biology with a focus on target identification. Furthermore, we discuss different strategies for direct target identification and the possibilities and challenges for plant biology.
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spelling pubmed-41094342014-08-07 Target identification strategies in plant chemical biology Dejonghe, Wim Russinova, Eugenia Front Plant Sci Plant Science The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies. Gene redundancy and lethality can substantially complicate research, which might be solved by applying a chemical genetics approach. Now understood as the study of small molecules and their effect on biological systems with subsequent target identification, chemical genetics is a fast developing field with a strong history in pharmaceutical research and drug discovery. In plant biology however, chemical genetics is still largely in the starting blocks, with most studies relying on forward genetics and phenotypic analysis for target identification, whereas studies including direct target identification are limited. Here, we provide an overview of recent advances in chemical genetics in plant biology with a focus on target identification. Furthermore, we discuss different strategies for direct target identification and the possibilities and challenges for plant biology. Frontiers Media S.A. 2014-07-24 /pmc/articles/PMC4109434/ /pubmed/25104953 http://dx.doi.org/10.3389/fpls.2014.00352 Text en Copyright © 2014 Dejonghe and Russinova. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Dejonghe, Wim
Russinova, Eugenia
Target identification strategies in plant chemical biology
title Target identification strategies in plant chemical biology
title_full Target identification strategies in plant chemical biology
title_fullStr Target identification strategies in plant chemical biology
title_full_unstemmed Target identification strategies in plant chemical biology
title_short Target identification strategies in plant chemical biology
title_sort target identification strategies in plant chemical biology
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109434/
https://www.ncbi.nlm.nih.gov/pubmed/25104953
http://dx.doi.org/10.3389/fpls.2014.00352
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