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Target identification strategies in plant chemical biology
The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies. Gene redundancy and lethality can substantially complicate research, which might be solved by applying a chemical genetics approach. Now...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109434/ https://www.ncbi.nlm.nih.gov/pubmed/25104953 http://dx.doi.org/10.3389/fpls.2014.00352 |
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author | Dejonghe, Wim Russinova, Eugenia |
author_facet | Dejonghe, Wim Russinova, Eugenia |
author_sort | Dejonghe, Wim |
collection | PubMed |
description | The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies. Gene redundancy and lethality can substantially complicate research, which might be solved by applying a chemical genetics approach. Now understood as the study of small molecules and their effect on biological systems with subsequent target identification, chemical genetics is a fast developing field with a strong history in pharmaceutical research and drug discovery. In plant biology however, chemical genetics is still largely in the starting blocks, with most studies relying on forward genetics and phenotypic analysis for target identification, whereas studies including direct target identification are limited. Here, we provide an overview of recent advances in chemical genetics in plant biology with a focus on target identification. Furthermore, we discuss different strategies for direct target identification and the possibilities and challenges for plant biology. |
format | Online Article Text |
id | pubmed-4109434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41094342014-08-07 Target identification strategies in plant chemical biology Dejonghe, Wim Russinova, Eugenia Front Plant Sci Plant Science The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies. Gene redundancy and lethality can substantially complicate research, which might be solved by applying a chemical genetics approach. Now understood as the study of small molecules and their effect on biological systems with subsequent target identification, chemical genetics is a fast developing field with a strong history in pharmaceutical research and drug discovery. In plant biology however, chemical genetics is still largely in the starting blocks, with most studies relying on forward genetics and phenotypic analysis for target identification, whereas studies including direct target identification are limited. Here, we provide an overview of recent advances in chemical genetics in plant biology with a focus on target identification. Furthermore, we discuss different strategies for direct target identification and the possibilities and challenges for plant biology. Frontiers Media S.A. 2014-07-24 /pmc/articles/PMC4109434/ /pubmed/25104953 http://dx.doi.org/10.3389/fpls.2014.00352 Text en Copyright © 2014 Dejonghe and Russinova. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Dejonghe, Wim Russinova, Eugenia Target identification strategies in plant chemical biology |
title | Target identification strategies in plant chemical biology |
title_full | Target identification strategies in plant chemical biology |
title_fullStr | Target identification strategies in plant chemical biology |
title_full_unstemmed | Target identification strategies in plant chemical biology |
title_short | Target identification strategies in plant chemical biology |
title_sort | target identification strategies in plant chemical biology |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109434/ https://www.ncbi.nlm.nih.gov/pubmed/25104953 http://dx.doi.org/10.3389/fpls.2014.00352 |
work_keys_str_mv | AT dejonghewim targetidentificationstrategiesinplantchemicalbiology AT russinovaeugenia targetidentificationstrategiesinplantchemicalbiology |