Cargando…

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

Bis-indolinone derivatives having either 2,6-disubstituted pyridine core (1a and 1b) or 1,10-disubstituted phenanthroline core (2a and 2b), already known to have antitumor activity, have been tested as potential G-quadruplex binders. Compounds 2a and 2b are able to selectively stabilize G-quadruplex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amato, Jussara, Iaccarino, Nunzia, Pagano, Bruno, Morigi, Rita, Locatelli, Alessandra, Leoni, Alberto, Rambaldi, Mirella, Zizza, Pasquale, Biroccio, Annamaria, Novellino, Ettore, Randazzo, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109613/ https://www.ncbi.nlm.nih.gov/pubmed/25105115 http://dx.doi.org/10.3389/fchem.2014.00054

Ejemplares similares

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein
por: Amato, Jussara, et al.
Publicado: (2019)

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells
por: Amato, Jussara, et al.
Publicado: (2020)

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance
por: Zizza, Pasquale, et al.
Publicado: (2016)

Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound
por: Marzano, Simona, et al.
Publicado: (2021)

Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds
por: Pagano, Alessia, et al.
Publicado: (2018)

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics
por: Rocca, Roberta, et al.
Publicado: (2020)

Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs
por: Lauri, Ilaria, et al.
Publicado: (2016)

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations
por: Moraca, Federica, et al.
Publicado: (2017)

G-Quadruplex Binders Induce Immunogenic Cell Death Markers in Aggressive Breast Cancer Cells
por: Di Somma, Sarah, et al.
Publicado: (2019)

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells
por: Marzano, Simona, et al.
Publicado: (2022)

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis
por: Salvati, Erica, et al.
Publicado: (2014)

Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study
por: Iaccarino, Nunzia, et al.
Publicado: (2019)

Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds
por: Di Porzio, Anna, et al.
Publicado: (2021)

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives
por: Ogloblina, Anna M., et al.
Publicado: (2020)

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy
por: Cherfils-Vicini, Julien, et al.
Publicado: (2014)

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis
por: Salvati, E., et al.
Publicado: (2014)

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds
por: Salvati, Erica, et al.
Publicado: (2015)

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19
por: Conti, Ilaria, et al.
Publicado: (2019)

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity
por: Bonvicini, Francesca, et al.
Publicado: (2022)

Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)](4)
por: Pagano, Bruno, et al.
Publicado: (2010)

Combination of dl922-947 Oncolytic Adenovirus and G-Quadruplex Binders Uncovers Improved Antitumor Activity in Breast Cancer
por: Napolitano, Fabiana, et al.
Publicado: (2022)

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
por: Iachettini, Sara, et al.
Publicado: (2013)

Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds
por: Platella, Chiara, et al.
Publicado: (2021)

Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography
por: Platella, Chiara, et al.
Publicado: (2020)

Selective Targeting of Cancer-Related G-Quadruplex Structures by the Natural Compound Dicentrine
por: Platella, Chiara, et al.
Publicado: (2023)

Effects of Sequence and Base Composition on the CD and TDS Profiles of i‐DNA
por: Iaccarino, Nunzia, et al.
Publicado: (2021)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy
por: Iachettini, Sara, et al.
Publicado: (2022)

Emerging roles of telomeric chromatin alterations in cancer
por: Cacchione, Stefano, et al.
Publicado: (2019)

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
por: Rizzo, Angela, et al.
Publicado: (2014)

Erratum: Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
por: Rizzo, Angela, et al.
Publicado: (2015)

Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells
por: Ambrosio, Maria Rosaria, et al.
Publicado: (2023)

Stability of telomeric G-quadruplexes
por: Tran, Phong Lan Thao, et al.
Publicado: (2011)

G-triplex structure and formation propensity
por: Cerofolini, Linda, et al.
Publicado: (2014)

Mechanistic insight into ligand binding to G-quadruplex DNA
por: Di Leva, Francesco Saverio, et al.
Publicado: (2014)

G-Quadruplexes at Telomeres: Friend or Foe?
por: Bryan, Tracy M.
Publicado: (2020)

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer
por: Porru, Manuela, et al.
Publicado: (2020)

Drug repositioning strategy for the identification of novel telomere‐damaging agents: A role for NAMPT inhibitors
por: Rizzo, Angela, et al.
Publicado: (2023)

Covalent ligation studies on the human telomere quadruplex
por: Qi, Jianying, et al.
Publicado: (2005)

Frustrated folding of guanine quadruplexes in telomeric DNA
por: Carrino, Simone, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_df8ulrrbip5p9o4le6kc1ncr4b