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Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients
The aim of the present study was to investigate the clinicopathologic/prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT), and thymidine phosphorylase (TP) proteins in postoperative non-small cell lung cancer (NSCLC) patients. Microarray slides from a set o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109640/ https://www.ncbi.nlm.nih.gov/pubmed/25114572 http://dx.doi.org/10.2147/OTT.S65067 |
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author | Zhao, Hong-Yun Ma, Guo-Wei Zou, Ben-Yan Li, Mei Lin, Su-Xia Zhao, Li-Ping Guo, Ying Huang, Yan Tian, Ying Xie, Dan Zhang, Li |
author_facet | Zhao, Hong-Yun Ma, Guo-Wei Zou, Ben-Yan Li, Mei Lin, Su-Xia Zhao, Li-Ping Guo, Ying Huang, Yan Tian, Ying Xie, Dan Zhang, Li |
author_sort | Zhao, Hong-Yun |
collection | PubMed |
description | The aim of the present study was to investigate the clinicopathologic/prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT), and thymidine phosphorylase (TP) proteins in postoperative non-small cell lung cancer (NSCLC) patients. Microarray slides from a set of 178 NSCLC patients were used for the detection of TS, OPRT, and TP expression by immunohistochemistry. The correlation between clinicopathologic factors and protein expression of three proteins was analyzed. Ninety seven carcinomas (57.4%) were TS-positive, 90 carcinomas (53.9%) were OPRT-positive, and 102 carcinomas (69.4%) were TP-positive. Compared with the TS-positive patients, the overall survival (OS) was significantly lower in the TS-negative patients (hazard ratio [HR] =1.766, 95% confidence interval [CI] =1.212–2.573, P=0.003). Significant differences between TS-positive and TS-negative patients was also observed in the following stratified analyses: 1) adenocarcinoma subgroup (HR =2.079, 95% CI =1.235–3.500, P=0.006); 2) less than 60-year-old subgroup (HR =1.890, 95% CI =1.061–3.366, P=0.031); 3) stage II/III subgroup (HR =1.594, 95% CI =1.036–2.453, P=0.034); and 4) surgery plus adjuvant therapy subgroup (HR =1.976, 95% CI =1.226–3.185, P=0.005). However, the OS was not significantly correlated with OPRT or TP protein expression. This study demonstrates that the TS level in tumor tissues may be a useful marker to predict the postoperative OS in NSCLC patients. |
format | Online Article Text |
id | pubmed-4109640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41096402014-08-11 Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients Zhao, Hong-Yun Ma, Guo-Wei Zou, Ben-Yan Li, Mei Lin, Su-Xia Zhao, Li-Ping Guo, Ying Huang, Yan Tian, Ying Xie, Dan Zhang, Li Onco Targets Ther Original Research The aim of the present study was to investigate the clinicopathologic/prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT), and thymidine phosphorylase (TP) proteins in postoperative non-small cell lung cancer (NSCLC) patients. Microarray slides from a set of 178 NSCLC patients were used for the detection of TS, OPRT, and TP expression by immunohistochemistry. The correlation between clinicopathologic factors and protein expression of three proteins was analyzed. Ninety seven carcinomas (57.4%) were TS-positive, 90 carcinomas (53.9%) were OPRT-positive, and 102 carcinomas (69.4%) were TP-positive. Compared with the TS-positive patients, the overall survival (OS) was significantly lower in the TS-negative patients (hazard ratio [HR] =1.766, 95% confidence interval [CI] =1.212–2.573, P=0.003). Significant differences between TS-positive and TS-negative patients was also observed in the following stratified analyses: 1) adenocarcinoma subgroup (HR =2.079, 95% CI =1.235–3.500, P=0.006); 2) less than 60-year-old subgroup (HR =1.890, 95% CI =1.061–3.366, P=0.031); 3) stage II/III subgroup (HR =1.594, 95% CI =1.036–2.453, P=0.034); and 4) surgery plus adjuvant therapy subgroup (HR =1.976, 95% CI =1.226–3.185, P=0.005). However, the OS was not significantly correlated with OPRT or TP protein expression. This study demonstrates that the TS level in tumor tissues may be a useful marker to predict the postoperative OS in NSCLC patients. Dove Medical Press 2014-07-16 /pmc/articles/PMC4109640/ /pubmed/25114572 http://dx.doi.org/10.2147/OTT.S65067 Text en © 2014 Zhao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhao, Hong-Yun Ma, Guo-Wei Zou, Ben-Yan Li, Mei Lin, Su-Xia Zhao, Li-Ping Guo, Ying Huang, Yan Tian, Ying Xie, Dan Zhang, Li Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title | Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_full | Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_fullStr | Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_full_unstemmed | Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_short | Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_sort | prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109640/ https://www.ncbi.nlm.nih.gov/pubmed/25114572 http://dx.doi.org/10.2147/OTT.S65067 |
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