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Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII

OBJECTIVE: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO) and baby hamster kidney cells (BHK). Previous studies, using the murine leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two recombinant human cell lines, HepG2 and Hek...

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Detalles Bibliográficos
Autores principales:	Correa de Freitas, Marcela Cristina, Fontes, Aparecida Maria, de Castilho Fernandes, Andrielle, Picanço-Castro, Virginia, de Sousa Russo, Elisa Maria, Covas, Dimas Tadeu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Hematologia e Hemoterapia 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109740/ https://www.ncbi.nlm.nih.gov/pubmed/25031062 http://dx.doi.org/10.1016/j.bjhh.2014.03.002

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