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Molecular mechanism of double Holliday junction dissolution
Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example, is catalysed by two enzymes that work in tight coordination and belong to the same ‘dissol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109787/ https://www.ncbi.nlm.nih.gov/pubmed/25061510 http://dx.doi.org/10.1186/2045-3701-4-36 |
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author | Swuec, Paolo Costa, Alessandro |
author_facet | Swuec, Paolo Costa, Alessandro |
author_sort | Swuec, Paolo |
collection | PubMed |
description | Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example, is catalysed by two enzymes that work in tight coordination and belong to the same ‘dissolvasome’ complex. Within the dissolvasome, the RecQ-like BLM helicase provides the translocase function for Holliday junction migration, while the topoisomerase III alpha-RMI1 subcomplex works as a proficient DNA decatenase, together resulting in double-Holliday-junction unlinking. Here, we review the available architectural and biochemical knowledge on the dissolvasome machinery, with a focus on the structural interplay between its components. |
format | Online Article Text |
id | pubmed-4109787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41097872014-07-25 Molecular mechanism of double Holliday junction dissolution Swuec, Paolo Costa, Alessandro Cell Biosci Review Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example, is catalysed by two enzymes that work in tight coordination and belong to the same ‘dissolvasome’ complex. Within the dissolvasome, the RecQ-like BLM helicase provides the translocase function for Holliday junction migration, while the topoisomerase III alpha-RMI1 subcomplex works as a proficient DNA decatenase, together resulting in double-Holliday-junction unlinking. Here, we review the available architectural and biochemical knowledge on the dissolvasome machinery, with a focus on the structural interplay between its components. BioMed Central 2014-07-09 /pmc/articles/PMC4109787/ /pubmed/25061510 http://dx.doi.org/10.1186/2045-3701-4-36 Text en Copyright © 2014 Swuec and Costa; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Swuec, Paolo Costa, Alessandro Molecular mechanism of double Holliday junction dissolution |
title | Molecular mechanism of double Holliday junction dissolution |
title_full | Molecular mechanism of double Holliday junction dissolution |
title_fullStr | Molecular mechanism of double Holliday junction dissolution |
title_full_unstemmed | Molecular mechanism of double Holliday junction dissolution |
title_short | Molecular mechanism of double Holliday junction dissolution |
title_sort | molecular mechanism of double holliday junction dissolution |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109787/ https://www.ncbi.nlm.nih.gov/pubmed/25061510 http://dx.doi.org/10.1186/2045-3701-4-36 |
work_keys_str_mv | AT swuecpaolo molecularmechanismofdoublehollidayjunctiondissolution AT costaalessandro molecularmechanismofdoublehollidayjunctiondissolution |