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Functional Diversification of Hsp40: Distinct J-Protein Functional Requirements for Two Prions Allow for Chaperone-Dependent Prion Selection

Yeast prions are heritable amyloid aggregates of functional yeast proteins; their propagation to subsequent cell generations is dependent upon fragmentation of prion protein aggregates by molecular chaperone proteins. Mounting evidence indicates the J-protein Sis1 may act as an amyloid specificity f...

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Detalles Bibliográficos
Autores principales:	Harris, Julia M., Nguyen, Phil P., Patel, Milan J., Sporn, Zachary A., Hines, Justin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109904/ https://www.ncbi.nlm.nih.gov/pubmed/25058638 http://dx.doi.org/10.1371/journal.pgen.1004510

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