Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action

BACKGROUND: Despite an overall decrease in incidence of and mortality from cancer, about 40% of Americans will be diagnosed with the disease in their lifetime, and around 20% will die of it. Current approaches to test carcinogenic chemicals adopt the 2-year rodent bioassay, which is costly and time-...

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Detalles Bibliográficos
Autores principales: Gusenleitner, Daniel, Auerbach, Scott S., Melia, Tisha, Gómez, Harold F., Sherr, David H., Monti, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109923/
https://www.ncbi.nlm.nih.gov/pubmed/25058030
http://dx.doi.org/10.1371/journal.pone.0102579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109923/
https://www.ncbi.nlm.nih.gov/pubmed/25058030
http://dx.doi.org/10.1371/journal.pone.0102579

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