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A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors

OBJECTIVE: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. METHODS: A...

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Autores principales: Huang, Yi, Huang, Jianrong, Lan, Huan, Zhao, GuanYan, Huang, ChunZhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109951/
https://www.ncbi.nlm.nih.gov/pubmed/25058491
http://dx.doi.org/10.1371/journal.pone.0102910
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author Huang, Yi
Huang, Jianrong
Lan, Huan
Zhao, GuanYan
Huang, ChunZhen
author_facet Huang, Yi
Huang, Jianrong
Lan, Huan
Zhao, GuanYan
Huang, ChunZhen
author_sort Huang, Yi
collection PubMed
description OBJECTIVE: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. METHODS: A systematic literature search was conducted in the Medline and Embase databases. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Dose–response meta-analysis was also performed for studies that reported categorical risk estimates for a series of smoking exposure levels. RESULTS: A total of 17 studies fulfilled the inclusion criteria. In the meta-analyses, the summary RRs (95% CIs) of CBT for maternal smoking during pregnancy, paternal smoking during pregnancy, maternal smoking before pregnancy, and paternal smoking before pregnancy were 0.96 (0.86–1.07), 1.09 (0.97–1.22), 0.93 (0.85–1.00), and 1.09 (1.00–1.20), respectively. Dose-response meta-analysis also showed no significant association between parental smoking and the risk of CBT. CONCLUSIONS: Findings from our meta-analysis indicate that parental smoking may not be associated with a risk of CBT.
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spelling pubmed-41099512014-07-29 A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors Huang, Yi Huang, Jianrong Lan, Huan Zhao, GuanYan Huang, ChunZhen PLoS One Research Article OBJECTIVE: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. METHODS: A systematic literature search was conducted in the Medline and Embase databases. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Dose–response meta-analysis was also performed for studies that reported categorical risk estimates for a series of smoking exposure levels. RESULTS: A total of 17 studies fulfilled the inclusion criteria. In the meta-analyses, the summary RRs (95% CIs) of CBT for maternal smoking during pregnancy, paternal smoking during pregnancy, maternal smoking before pregnancy, and paternal smoking before pregnancy were 0.96 (0.86–1.07), 1.09 (0.97–1.22), 0.93 (0.85–1.00), and 1.09 (1.00–1.20), respectively. Dose-response meta-analysis also showed no significant association between parental smoking and the risk of CBT. CONCLUSIONS: Findings from our meta-analysis indicate that parental smoking may not be associated with a risk of CBT. Public Library of Science 2014-07-24 /pmc/articles/PMC4109951/ /pubmed/25058491 http://dx.doi.org/10.1371/journal.pone.0102910 Text en © 2014 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huang, Yi
Huang, Jianrong
Lan, Huan
Zhao, GuanYan
Huang, ChunZhen
A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors
title A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors
title_full A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors
title_fullStr A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors
title_full_unstemmed A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors
title_short A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors
title_sort meta-analysis of parental smoking and the risk of childhood brain tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109951/
https://www.ncbi.nlm.nih.gov/pubmed/25058491
http://dx.doi.org/10.1371/journal.pone.0102910
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