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Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas

BACKGROUND: There are limited data examining healthcare resource utilization in patients with recurrent Clostridium difficile infection (CDI). METHODS: Patients with CDI at a tertiary-care hospital in Houston, TX, were prospectively enrolled into an observational cohort study. Recurrence was assesse...

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Autores principales: Aitken, Samuel L., Joseph, Tiby B., Shah, Dhara N., Lasco, Todd M., Palmer, Hannah R., DuPont, Herbert L., Xie, Yang, Garey, Kevin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109955/
https://www.ncbi.nlm.nih.gov/pubmed/25057871
http://dx.doi.org/10.1371/journal.pone.0102848
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author Aitken, Samuel L.
Joseph, Tiby B.
Shah, Dhara N.
Lasco, Todd M.
Palmer, Hannah R.
DuPont, Herbert L.
Xie, Yang
Garey, Kevin W.
author_facet Aitken, Samuel L.
Joseph, Tiby B.
Shah, Dhara N.
Lasco, Todd M.
Palmer, Hannah R.
DuPont, Herbert L.
Xie, Yang
Garey, Kevin W.
author_sort Aitken, Samuel L.
collection PubMed
description BACKGROUND: There are limited data examining healthcare resource utilization in patients with recurrent Clostridium difficile infection (CDI). METHODS: Patients with CDI at a tertiary-care hospital in Houston, TX, were prospectively enrolled into an observational cohort study. Recurrence was assessed via follow-up phone calls. Patients with one or more recurrence were included in this study. The location at which healthcare was obtained by patients with recurrent CDI was identified along with hospital length of stay. CDI-attributable readmissions, defined as a positive toxin test within 48 hours of admission and a primary CDI diagnosis, were also assessed. RESULTS: 372 primary cases of CDI were identified of whom 64 (17.2%) experienced at least one CDI recurrence. Twelve of 64 patients experienced 18 further episodes of CDI recurrence. Of these 64 patients, 33 (50.8%) patients with recurrent CDI were readmitted of which 6 (18.2%) required ICU care, 29 (45.3%) had outpatient care only, and 2 (3.1%) had an ED visit. Nineteen (55.9%) readmissions were defined as CDI-attributable. For patients with CDI-attributable readmission, the average length of stay was 6±6 days. CONCLUSION: Recurrent CDI leads to significant healthcare resource utilization. Methods of reducing the burden of recurrent CDI should be further studied.
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spelling pubmed-41099552014-07-29 Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas Aitken, Samuel L. Joseph, Tiby B. Shah, Dhara N. Lasco, Todd M. Palmer, Hannah R. DuPont, Herbert L. Xie, Yang Garey, Kevin W. PLoS One Research Article BACKGROUND: There are limited data examining healthcare resource utilization in patients with recurrent Clostridium difficile infection (CDI). METHODS: Patients with CDI at a tertiary-care hospital in Houston, TX, were prospectively enrolled into an observational cohort study. Recurrence was assessed via follow-up phone calls. Patients with one or more recurrence were included in this study. The location at which healthcare was obtained by patients with recurrent CDI was identified along with hospital length of stay. CDI-attributable readmissions, defined as a positive toxin test within 48 hours of admission and a primary CDI diagnosis, were also assessed. RESULTS: 372 primary cases of CDI were identified of whom 64 (17.2%) experienced at least one CDI recurrence. Twelve of 64 patients experienced 18 further episodes of CDI recurrence. Of these 64 patients, 33 (50.8%) patients with recurrent CDI were readmitted of which 6 (18.2%) required ICU care, 29 (45.3%) had outpatient care only, and 2 (3.1%) had an ED visit. Nineteen (55.9%) readmissions were defined as CDI-attributable. For patients with CDI-attributable readmission, the average length of stay was 6±6 days. CONCLUSION: Recurrent CDI leads to significant healthcare resource utilization. Methods of reducing the burden of recurrent CDI should be further studied. Public Library of Science 2014-07-24 /pmc/articles/PMC4109955/ /pubmed/25057871 http://dx.doi.org/10.1371/journal.pone.0102848 Text en © 2014 Aitken et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Aitken, Samuel L.
Joseph, Tiby B.
Shah, Dhara N.
Lasco, Todd M.
Palmer, Hannah R.
DuPont, Herbert L.
Xie, Yang
Garey, Kevin W.
Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas
title Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas
title_full Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas
title_fullStr Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas
title_full_unstemmed Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas
title_short Healthcare Resource Utilization for Recurrent Clostridium difficile Infection in a Large University Hospital in Houston, Texas
title_sort healthcare resource utilization for recurrent clostridium difficile infection in a large university hospital in houston, texas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109955/
https://www.ncbi.nlm.nih.gov/pubmed/25057871
http://dx.doi.org/10.1371/journal.pone.0102848
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