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Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study
BACKGROUND: We aimed to calculate 3-year incidence of multimorbidity, defined as the development of two or more chronic diseases in a population of older people free from multimorbidity at baseline. Secondly, we aimed to identify predictors of incident multimorbidity amongst life-style related indic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109993/ https://www.ncbi.nlm.nih.gov/pubmed/25058497 http://dx.doi.org/10.1371/journal.pone.0103120 |
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author | Melis, René Marengoni, Alessandra Angleman, Sara Fratiglioni, Laura |
author_facet | Melis, René Marengoni, Alessandra Angleman, Sara Fratiglioni, Laura |
author_sort | Melis, René |
collection | PubMed |
description | BACKGROUND: We aimed to calculate 3-year incidence of multimorbidity, defined as the development of two or more chronic diseases in a population of older people free from multimorbidity at baseline. Secondly, we aimed to identify predictors of incident multimorbidity amongst life-style related indicators, medical conditions and biomarkers. METHODS: Data were gathered from 418 participants in the first follow up of the Kungsholmen Project (Stockholm, Sweden, 1991–1993, 78+ years old) who were not affected by multimorbidity (149 had none disease and 269 one disease), including a social interview, a neuropsychological battery and a medical examination. RESULTS: After 3 years, 33.6% of participants who were without disease and 66.4% of those with one disease at baseline, developed multimorbidity: the incidence rate was 12.6 per 100 person-years (95% CI: 9.2–16.7) and 32.9 per 100 person-years (95% CI: 28.1–38.3), respectively. After adjustments, worse cognitive function (OR, 95% CI, for 1 point lower Mini-Mental State Examination: 1.22, 1.00–1.48) was associated with increased risk of multimorbidity among subjects with no disease at baseline. Higher age was the only predictor of multimorbidity in persons with one disease at baseline. CONCLUSIONS: Multimorbidity has a high incidence at old age. Mental health-related symptoms are likely predictors of multimorbidity, suggesting a strong impact of mental disorders on the health of older people. |
format | Online Article Text |
id | pubmed-4109993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41099932014-07-29 Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study Melis, René Marengoni, Alessandra Angleman, Sara Fratiglioni, Laura PLoS One Research Article BACKGROUND: We aimed to calculate 3-year incidence of multimorbidity, defined as the development of two or more chronic diseases in a population of older people free from multimorbidity at baseline. Secondly, we aimed to identify predictors of incident multimorbidity amongst life-style related indicators, medical conditions and biomarkers. METHODS: Data were gathered from 418 participants in the first follow up of the Kungsholmen Project (Stockholm, Sweden, 1991–1993, 78+ years old) who were not affected by multimorbidity (149 had none disease and 269 one disease), including a social interview, a neuropsychological battery and a medical examination. RESULTS: After 3 years, 33.6% of participants who were without disease and 66.4% of those with one disease at baseline, developed multimorbidity: the incidence rate was 12.6 per 100 person-years (95% CI: 9.2–16.7) and 32.9 per 100 person-years (95% CI: 28.1–38.3), respectively. After adjustments, worse cognitive function (OR, 95% CI, for 1 point lower Mini-Mental State Examination: 1.22, 1.00–1.48) was associated with increased risk of multimorbidity among subjects with no disease at baseline. Higher age was the only predictor of multimorbidity in persons with one disease at baseline. CONCLUSIONS: Multimorbidity has a high incidence at old age. Mental health-related symptoms are likely predictors of multimorbidity, suggesting a strong impact of mental disorders on the health of older people. Public Library of Science 2014-07-24 /pmc/articles/PMC4109993/ /pubmed/25058497 http://dx.doi.org/10.1371/journal.pone.0103120 Text en © 2014 Melis et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Melis, René Marengoni, Alessandra Angleman, Sara Fratiglioni, Laura Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study |
title | Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study |
title_full | Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study |
title_fullStr | Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study |
title_full_unstemmed | Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study |
title_short | Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study |
title_sort | incidence and predictors of multimorbidity in the elderly: a population-based longitudinal study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109993/ https://www.ncbi.nlm.nih.gov/pubmed/25058497 http://dx.doi.org/10.1371/journal.pone.0103120 |
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