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Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes

BACKGROUND: The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is a multi-functional protein that has been implicated in regulation of cell growth and apoptosis. Cardiac myocytes express relatively high levels of M6P/IGF2R, and cardiomyocyte apoptosis has been identified in a...

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Detalles Bibliográficos
Autores principales: Chen, Zhihong, Ge, Yinlin, Kang, Jing X
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411032/
https://www.ncbi.nlm.nih.gov/pubmed/15115542
http://dx.doi.org/10.1186/1471-2121-5-15