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Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?

Computational models predict that focal damage to the Default Mode Network (DMN) causes widespread decreases and increases of functional DMN connectivity. How such alterations impact functioning in a specific cognitive domain such as episodic memory remains relatively unexplored. Here, we show in pa...

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Detalles Bibliográficos
Autores principales: McCormick, Cornelia, Protzner, Andrea B., Barnett, Alexander J., Cohn, Melanie, Valiante, Taufik A., McAndrews, Mary Pat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110351/
https://www.ncbi.nlm.nih.gov/pubmed/25068108
http://dx.doi.org/10.1016/j.nicl.2014.05.008
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author McCormick, Cornelia
Protzner, Andrea B.
Barnett, Alexander J.
Cohn, Melanie
Valiante, Taufik A.
McAndrews, Mary Pat
author_facet McCormick, Cornelia
Protzner, Andrea B.
Barnett, Alexander J.
Cohn, Melanie
Valiante, Taufik A.
McAndrews, Mary Pat
author_sort McCormick, Cornelia
collection PubMed
description Computational models predict that focal damage to the Default Mode Network (DMN) causes widespread decreases and increases of functional DMN connectivity. How such alterations impact functioning in a specific cognitive domain such as episodic memory remains relatively unexplored. Here, we show in patients with unilateral medial temporal lobe epilepsy (mTLE) that focal structural damage leads indeed to specific patterns of DMN functional connectivity alterations, specifically decreased connectivity between both medial temporal lobes (MTLs) and the posterior part of the DMN and increased intrahemispheric anterior–posterior connectivity. Importantly, these patterns were associated with better and worse episodic memory capacity, respectively. These distinct patterns, shown here for the first time, suggest that a close dialogue between both MTLs and the posterior components of the DMN is required to fully express the extensive repertoire of episodic memory abilities.
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spelling pubmed-41103512014-07-25 Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage? McCormick, Cornelia Protzner, Andrea B. Barnett, Alexander J. Cohn, Melanie Valiante, Taufik A. McAndrews, Mary Pat Neuroimage Clin Article Computational models predict that focal damage to the Default Mode Network (DMN) causes widespread decreases and increases of functional DMN connectivity. How such alterations impact functioning in a specific cognitive domain such as episodic memory remains relatively unexplored. Here, we show in patients with unilateral medial temporal lobe epilepsy (mTLE) that focal structural damage leads indeed to specific patterns of DMN functional connectivity alterations, specifically decreased connectivity between both medial temporal lobes (MTLs) and the posterior part of the DMN and increased intrahemispheric anterior–posterior connectivity. Importantly, these patterns were associated with better and worse episodic memory capacity, respectively. These distinct patterns, shown here for the first time, suggest that a close dialogue between both MTLs and the posterior components of the DMN is required to fully express the extensive repertoire of episodic memory abilities. Elsevier 2014-05-16 /pmc/articles/PMC4110351/ /pubmed/25068108 http://dx.doi.org/10.1016/j.nicl.2014.05.008 Text en © 2014 The Authors. Published by Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
McCormick, Cornelia
Protzner, Andrea B.
Barnett, Alexander J.
Cohn, Melanie
Valiante, Taufik A.
McAndrews, Mary Pat
Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?
title Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?
title_full Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?
title_fullStr Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?
title_full_unstemmed Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?
title_short Linking DMN connectivity to episodic memory capacity: What can we learn from patients with medial temporal lobe damage?
title_sort linking dmn connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110351/
https://www.ncbi.nlm.nih.gov/pubmed/25068108
http://dx.doi.org/10.1016/j.nicl.2014.05.008
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