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The effect of cigarette smoking on the clinical course of inflammatory bowel disease
INTRODUCTION: Cigarette smoking is considered an important risk factor for developing Crohn's disease (CD), contributing to a more severe course of the disease. Conversely, smoking is believed to have a beneficial effect on the course of ulcerative colitis (UC), a second major condition of infl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110362/ https://www.ncbi.nlm.nih.gov/pubmed/25097712 http://dx.doi.org/10.5114/pg.2014.43577 |
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author | Karczewski, Jacek Poniedziałek, Barbara Rzymski, Piotr Rychlewska-Hańczewska, Anna Adamski, Zygmunt Wiktorowicz, Krzysztof |
author_facet | Karczewski, Jacek Poniedziałek, Barbara Rzymski, Piotr Rychlewska-Hańczewska, Anna Adamski, Zygmunt Wiktorowicz, Krzysztof |
author_sort | Karczewski, Jacek |
collection | PubMed |
description | INTRODUCTION: Cigarette smoking is considered an important risk factor for developing Crohn's disease (CD), contributing to a more severe course of the disease. Conversely, smoking is believed to have a beneficial effect on the course of ulcerative colitis (UC), a second major condition of inflammatory bowel disease (IBD). AIM: To investigate the effect of tobacco use on the clinical course of IBD. MATERIAL AND METHODS: A group of 95 adults with IBD were enrolled to the study. Demographic and clinical data of patients as well as their smoking status were analysed based on their medical history. Values were considered significant when p ≤ 0.05. RESULTS: Current smokers constituted the majority of CD patients. They tended to develop a more severe course of the disease, compared to former smokers and non-smokers. Current smokers suffered a moderate-to-severe form of the disease and required immunosuppressive therapy more frequently. They were also hospitalised and underwent surgeries more frequently than patients from other investigated subgroups. The study failed, however, to fully confirm the beneficial effect of smoking on the clinical outcome of UC. The investigated non-smokers and former smokers suffered a more severe disease, but the analysis did not find any statistical differences in the frequencies of hospitalisations nor immunosuppressant usage among the investigated subgroups. CONCLUSIONS: The study confirmed a detrimental effect of smoking on the outcome of CD, but failed to fully confirm its beneficial effect on UC. |
format | Online Article Text |
id | pubmed-4110362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-41103622014-08-05 The effect of cigarette smoking on the clinical course of inflammatory bowel disease Karczewski, Jacek Poniedziałek, Barbara Rzymski, Piotr Rychlewska-Hańczewska, Anna Adamski, Zygmunt Wiktorowicz, Krzysztof Prz Gastroenterol Original Paper INTRODUCTION: Cigarette smoking is considered an important risk factor for developing Crohn's disease (CD), contributing to a more severe course of the disease. Conversely, smoking is believed to have a beneficial effect on the course of ulcerative colitis (UC), a second major condition of inflammatory bowel disease (IBD). AIM: To investigate the effect of tobacco use on the clinical course of IBD. MATERIAL AND METHODS: A group of 95 adults with IBD were enrolled to the study. Demographic and clinical data of patients as well as their smoking status were analysed based on their medical history. Values were considered significant when p ≤ 0.05. RESULTS: Current smokers constituted the majority of CD patients. They tended to develop a more severe course of the disease, compared to former smokers and non-smokers. Current smokers suffered a moderate-to-severe form of the disease and required immunosuppressive therapy more frequently. They were also hospitalised and underwent surgeries more frequently than patients from other investigated subgroups. The study failed, however, to fully confirm the beneficial effect of smoking on the clinical outcome of UC. The investigated non-smokers and former smokers suffered a more severe disease, but the analysis did not find any statistical differences in the frequencies of hospitalisations nor immunosuppressant usage among the investigated subgroups. CONCLUSIONS: The study confirmed a detrimental effect of smoking on the outcome of CD, but failed to fully confirm its beneficial effect on UC. Termedia Publishing House 2014-06-26 2014 /pmc/articles/PMC4110362/ /pubmed/25097712 http://dx.doi.org/10.5114/pg.2014.43577 Text en Copyright © 2014 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Karczewski, Jacek Poniedziałek, Barbara Rzymski, Piotr Rychlewska-Hańczewska, Anna Adamski, Zygmunt Wiktorowicz, Krzysztof The effect of cigarette smoking on the clinical course of inflammatory bowel disease |
title | The effect of cigarette smoking on the clinical course of inflammatory bowel disease |
title_full | The effect of cigarette smoking on the clinical course of inflammatory bowel disease |
title_fullStr | The effect of cigarette smoking on the clinical course of inflammatory bowel disease |
title_full_unstemmed | The effect of cigarette smoking on the clinical course of inflammatory bowel disease |
title_short | The effect of cigarette smoking on the clinical course of inflammatory bowel disease |
title_sort | effect of cigarette smoking on the clinical course of inflammatory bowel disease |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110362/ https://www.ncbi.nlm.nih.gov/pubmed/25097712 http://dx.doi.org/10.5114/pg.2014.43577 |
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