[HCO(3)(-)]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells

BACKGROUND: Bicarbonate activated Soluble Adenylyl Cyclase (sAC) is a unique cytoplasmic and nuclear signaling mechanism for the generation of cAMP. HCO(3)(- )activates sAC in bovine corneal endothelial cells (BCECs), increasing [cAMP] and stimulating PKA, leading to phosphorylation of the cystic fi...

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Detalles Bibliográficos
Autores principales: Sun, Xing Cai, Cui, Miao, Bonanno, Joseph A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411047/
https://www.ncbi.nlm.nih.gov/pubmed/15117409
http://dx.doi.org/10.1186/1472-6793-4-8

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