Sequence-based detection of mutations in cadherin 1 to determine the prevalence of germline mutations in patients with invasive lobular carcinoma of the breast

BACKGROUND: Loss of cadherin 1 (CDH1) expression, which is normally involved in cell adhesion and maintenance of tissue architecture, is a hallmark of invasive lobular carcinoma (ILCA). Because hereditary cancers may require different risk reduction, counseling and treatment options than sporadic ca...

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Detalles Bibliográficos
Autores principales: Valente, Allyson L, Rummel, Seth, Shriver, Craig D, Ellsworth, Rachel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110519/
https://www.ncbi.nlm.nih.gov/pubmed/25067988
http://dx.doi.org/10.1186/1897-4287-12-17

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