Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family

BACKGROUND: The introduction of cisplatin has improved the long-term survival rate in osteosarcoma patients. However, some patients are intrinsically resistant to cisplatin. This study reported that the activation of Notch1 is positively correlated with cisplatin sensitivity, evidenced by both clini...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Jin, Fangchun, Qin, An, Hao, Yongqiang, Dong, Yufeng, Ge, Shengfang, Dai, Kerong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110525/
https://www.ncbi.nlm.nih.gov/pubmed/24894297
http://dx.doi.org/10.1186/1476-4598-13-139

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