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Microfluidics in biotechnology
Microfluidics enables biotechnological processes to proceed on a scale (microns) at which physical processes such as osmotic movement, electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced, and procedural costs are lowered. Th...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411055/ https://www.ncbi.nlm.nih.gov/pubmed/15056390 http://dx.doi.org/10.1186/1477-3155-2-2 |
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author | Barry, Richard Ivanov, Dimitri |
author_facet | Barry, Richard Ivanov, Dimitri |
author_sort | Barry, Richard |
collection | PubMed |
description | Microfluidics enables biotechnological processes to proceed on a scale (microns) at which physical processes such as osmotic movement, electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced, and procedural costs are lowered. The versatility of microfluidic devices allows interfacing with current methods and technologies. Microfluidics has been applied to DNA analysis methods and shown to accelerate DNA microarray assay hybridisation times. The linking of microfluidics to protein analysis techologies, e.g. mass spectrometry, enables picomole amounts of peptide to be analysed within a controlled micro-environment. The flexibility of microfluidics will facilitate its exploitation in assay development across multiple biotechnological disciplines. |
format | Text |
id | pubmed-411055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-4110552004-05-19 Microfluidics in biotechnology Barry, Richard Ivanov, Dimitri J Nanobiotechnology Review Microfluidics enables biotechnological processes to proceed on a scale (microns) at which physical processes such as osmotic movement, electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced, and procedural costs are lowered. The versatility of microfluidic devices allows interfacing with current methods and technologies. Microfluidics has been applied to DNA analysis methods and shown to accelerate DNA microarray assay hybridisation times. The linking of microfluidics to protein analysis techologies, e.g. mass spectrometry, enables picomole amounts of peptide to be analysed within a controlled micro-environment. The flexibility of microfluidics will facilitate its exploitation in assay development across multiple biotechnological disciplines. BioMed Central 2004-03-31 /pmc/articles/PMC411055/ /pubmed/15056390 http://dx.doi.org/10.1186/1477-3155-2-2 Text en Copyright © 2004 Barry and Ivanov; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Review Barry, Richard Ivanov, Dimitri Microfluidics in biotechnology |
title | Microfluidics in biotechnology |
title_full | Microfluidics in biotechnology |
title_fullStr | Microfluidics in biotechnology |
title_full_unstemmed | Microfluidics in biotechnology |
title_short | Microfluidics in biotechnology |
title_sort | microfluidics in biotechnology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411055/ https://www.ncbi.nlm.nih.gov/pubmed/15056390 http://dx.doi.org/10.1186/1477-3155-2-2 |
work_keys_str_mv | AT barryrichard microfluidicsinbiotechnology AT ivanovdimitri microfluidicsinbiotechnology |