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Local BMP-SMAD1 Signaling Increases LIF Receptor-Dependent STAT3 Responsiveness and Primed-to-Naive Mouse Pluripotent Stem Cell Conversion Frequency

Conversion of EpiSCs to naive ESCs is a rare event that is driven by the reestablishment of the naive transcription factor network. In mice, STAT3 activation is sufficient to drive conversion of EpiSCs to the naive pluripotent stem cell (PSC) state. However, the lack of responsiveness of EpiSCs to L...

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Detalles Bibliográficos
Autores principales:	Onishi, Kento, Tonge, Peter D., Nagy, Andras, Zandstra, Peter W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110772/ https://www.ncbi.nlm.nih.gov/pubmed/25068129 http://dx.doi.org/10.1016/j.stemcr.2014.04.019

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