Similarity of GATA-3 Expression between Rat and Human Mammary Glands

The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal...

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Autores principales: Kinoshita, Yuichi, Yoshizawa, Katsuhiko, Emoto, Yuko, Yuki, Michiko, Yuri, Takashi, Shikata, Nobuaki, Tsubura, Airo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110942/
https://www.ncbi.nlm.nih.gov/pubmed/25352719
http://dx.doi.org/10.1293/tox.2014-0008
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author Kinoshita, Yuichi
Yoshizawa, Katsuhiko
Emoto, Yuko
Yuki, Michiko
Yuri, Takashi
Shikata, Nobuaki
Tsubura, Airo
author_facet Kinoshita, Yuichi
Yoshizawa, Katsuhiko
Emoto, Yuko
Yuki, Michiko
Yuri, Takashi
Shikata, Nobuaki
Tsubura, Airo
author_sort Kinoshita, Yuichi
collection PubMed
description The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans.
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spelling pubmed-41109422014-10-28 Similarity of GATA-3 Expression between Rat and Human Mammary Glands Kinoshita, Yuichi Yoshizawa, Katsuhiko Emoto, Yuko Yuki, Michiko Yuri, Takashi Shikata, Nobuaki Tsubura, Airo J Toxicol Pathol Short Communication The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans. Japanese Society of Toxicologic Pathology 2014-05-14 2014-07 /pmc/articles/PMC4110942/ /pubmed/25352719 http://dx.doi.org/10.1293/tox.2014-0008 Text en ©2014 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Short Communication
Kinoshita, Yuichi
Yoshizawa, Katsuhiko
Emoto, Yuko
Yuki, Michiko
Yuri, Takashi
Shikata, Nobuaki
Tsubura, Airo
Similarity of GATA-3 Expression between Rat and Human Mammary Glands
title Similarity of GATA-3 Expression between Rat and Human Mammary Glands
title_full Similarity of GATA-3 Expression between Rat and Human Mammary Glands
title_fullStr Similarity of GATA-3 Expression between Rat and Human Mammary Glands
title_full_unstemmed Similarity of GATA-3 Expression between Rat and Human Mammary Glands
title_short Similarity of GATA-3 Expression between Rat and Human Mammary Glands
title_sort similarity of gata-3 expression between rat and human mammary glands
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110942/
https://www.ncbi.nlm.nih.gov/pubmed/25352719
http://dx.doi.org/10.1293/tox.2014-0008
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