Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus

The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure t...

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Autores principales: Lakhina, Vanisha, Subramanian, Lakshmi, Huilgol, Dhananjay, Shetty, Ashwin S, Vaidya, Vidita A., Tole, Shubha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111125/
https://www.ncbi.nlm.nih.gov/pubmed/25110573
http://dx.doi.org/10.12688/f1000research.2-205.v1
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author Lakhina, Vanisha
Subramanian, Lakshmi
Huilgol, Dhananjay
Shetty, Ashwin S
Vaidya, Vidita A.
Tole, Shubha
author_facet Lakhina, Vanisha
Subramanian, Lakshmi
Huilgol, Dhananjay
Shetty, Ashwin S
Vaidya, Vidita A.
Tole, Shubha
author_sort Lakhina, Vanisha
collection PubMed
description The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure that displays striking activity dependent plasticity.  We examined whether LIM-HD genes and their co-factors are regulated during kainic acid induced seizure in the adult rat hippocampus as well as in early postnatal rats, when the hippocampal circuitry is not fully developed.  We report a distinct and field-specific regulation of LIM-HD genes Lhx1, Lhx2, and Lhx9, LIM-only gene Lmo4, and cofactor Clim1a in the adult hippocampus after seizure induction. In contrast none of these genes displayed altered levels upon induction of seizure in postnatal animals.  Our results provide evidence of temporal and spatial seizure mediated regulation of LIM-HD family members and suggest that LIM-HD gene function may be involved in activity dependent plasticity in the adult hippocampus
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spelling pubmed-41111252014-08-07 Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus Lakhina, Vanisha Subramanian, Lakshmi Huilgol, Dhananjay Shetty, Ashwin S Vaidya, Vidita A. Tole, Shubha F1000Res Research Article The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure that displays striking activity dependent plasticity.  We examined whether LIM-HD genes and their co-factors are regulated during kainic acid induced seizure in the adult rat hippocampus as well as in early postnatal rats, when the hippocampal circuitry is not fully developed.  We report a distinct and field-specific regulation of LIM-HD genes Lhx1, Lhx2, and Lhx9, LIM-only gene Lmo4, and cofactor Clim1a in the adult hippocampus after seizure induction. In contrast none of these genes displayed altered levels upon induction of seizure in postnatal animals.  Our results provide evidence of temporal and spatial seizure mediated regulation of LIM-HD family members and suggest that LIM-HD gene function may be involved in activity dependent plasticity in the adult hippocampus F1000Research 2013-10-04 /pmc/articles/PMC4111125/ /pubmed/25110573 http://dx.doi.org/10.12688/f1000research.2-205.v1 Text en Copyright: © 2013 Lakhina V et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
spellingShingle Research Article
Lakhina, Vanisha
Subramanian, Lakshmi
Huilgol, Dhananjay
Shetty, Ashwin S
Vaidya, Vidita A.
Tole, Shubha
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus
title Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus
title_full Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus
title_fullStr Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus
title_full_unstemmed Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus
title_short Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus
title_sort seizure evoked regulation of lim-hd genes and co-factors in the postnatal and adult hippocampus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111125/
https://www.ncbi.nlm.nih.gov/pubmed/25110573
http://dx.doi.org/10.12688/f1000research.2-205.v1
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