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Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

[Image: see text] Many modular polyketide synthases harbor one or more redox-inactive domains of unknown function that are highly homologous to ketoreductase (KR) domains. A newly developed tandem equilibrium isotope exchange (EIX) assay has now established that such “KR(0)” domains catalyze the bio...

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Detalles Bibliográficos
Autores principales:	Garg, Ashish, Xie, Xinqiang, Keatinge-Clay, Adrian, Khosla, Chaitan, Cane, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111212/ https://www.ncbi.nlm.nih.gov/pubmed/25004372 http://dx.doi.org/10.1021/ja5056998

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