Cargando…

Intoxication of Host Cells by the T3SS Phospholipase ExoU: PI(4,5)P(2)-Associated, Cytoskeletal Collapse and Late Phase Membrane Blebbing

Pseudomonas aeruginosa is an opportunistic pathogen that is associated with hospital-acquired infections, ventilator-associated pneumonia, and morbidity of immunocompromised individuals. A subpopulation of P. aeruginosa encodes a protein, ExoU, which exhibits acute cytotoxicity. Toxicity is directly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sato, Hiromi, Frank, Dara W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111512/ https://www.ncbi.nlm.nih.gov/pubmed/25061861 http://dx.doi.org/10.1371/journal.pone.0103127

Ejemplares similares

Characterization of the ExoU activation mechanism using EPR and integrative modeling
por: Tessmer, Maxx H., et al.
Publicado: (2020)

Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration
por: Pazos, Michael A., et al.
Publicado: (2017)

The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages
por: Ozer, Egon A, et al.
Publicado: (2019)

Association between possession of ExoU and antibiotic resistance in Pseudomonas aeruginosa
por: Subedi, Dinesh, et al.
Publicado: (2018)

Presence of exoY, exoS, exoU and exoT genes, antibiotic resistance and biofilm production among Pseudomonas aeruginosa isolates in Northwest Iran
por: Azimi, Somayeh, et al.
Publicado: (2016)

Type III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia
por: Howell, Heather A., et al.
Publicado: (2013)

Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs
por: Sawa, Teiji, et al.
Publicado: (2016)

Pseudomonas aeruginosa Toxin ExoU as a Therapeutic Target in the Treatment of Bacterial Infections
por: Foulkes, Daniel M., et al.
Publicado: (2019)

Pseudomonas aeruginosa ExoU-associated virulence in HCT recipients and patients with hematologic malignancies
por: Fontana, Lauren, et al.
Publicado: (2023)

Utilizing in silico and in vitro methods to identify possible binding sites of a novel ligand against Pseudomonas aeruginosa phospholipase toxin ExoU
por: Chamberlain, Krista, et al.
Publicado: (2021)

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU
por: Halavaty, Andrei S., et al.
Publicado: (2012)

The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
por: Deruelle, Vincent, et al.
Publicado: (2021)

Emergence of ST463 exoU-Positive, Imipenem-Nonsusceptible Pseudomonas aeruginosa Isolates in China
por: Zhu, Ying, et al.
Publicado: (2023)

Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology
por: Bagayoko, Salimata, et al.
Publicado: (2021)

Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection
por: Hardy, Kierra S., et al.
Publicado: (2021)

Structural Basis of Cytotoxicity Mediated by the Type III Secretion Toxin ExoU from Pseudomonas aeruginosa
por: Gendrin, Claire, et al.
Publicado: (2012)

Structure and Dynamics of Type III Secretion Effector Protein ExoU As determined by SDSL-EPR Spectroscopy in Conjunction with De Novo Protein Folding
por: Fischer, Axel W., et al.
Publicado: (2017)

ExoU-induced redox imbalance and oxidative stress in airway epithelial cells during Pseudomonas aeruginosa pneumosepsis
por: da Cunha, Luiz Gonzaga, et al.
Publicado: (2015)

High frequency of the exoU+/exoS+ genotype associated with multidrug-resistant “high-risk clones” of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals
por: Horna, Gertrudis, et al.
Publicado: (2019)

ExoU Activates NF-κB and Increases IL-8/KC Secretion during Pseudomonas aeruginosa Infection
por: de Lima, Carolina Diettrich Mallet, et al.
Publicado: (2012)

Phenotypic and Genomic Comparison of the Two Most Common ExoU-Positive Pseudomonas aeruginosa Clones, PA14 and ST235
por: Fischer, Sebastian, et al.
Publicado: (2020)

ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection
por: Hardy, Kierra S., et al.
Publicado: (2022)

Shape remodeling and blebbing of active cytoskeletal vesicles
por: Loiseau, Etienne, et al.
Publicado: (2016)

The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model
por: Hardy, Kierra S., et al.
Publicado: (2022)

Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis
por: Machado, Gloria-Beatriz, et al.
Publicado: (2011)

Simulated Cytoskeletal Collapse via Tau Degradation
por: Sendek, Austin, et al.
Publicado: (2014)

Results of open bleb revision as management of primary bleb failure following XEN 45 gel stent and Preserflo™ Microshunt
por: Theilig, Theresa, et al.
Publicado: (2023)

Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse
por: Wyatt, Jasmine, et al.
Publicado: (2023)

Extracellular phospholipase A(2): causative agent in circulatory collapse of septic shock?
por: Vadas, P., et al.
Publicado: (1988)

Defunct brain stem cardiovascular regulation underlies cardiovascular collapse associated with methamphetamine intoxication
por: Li, Faith CH, et al.
Publicado: (2012)

Modification to T.I.K. tank SS 45
por: Betty, G
Publicado: (1974)

Needling and open filtering bleb revision after XEN-45 implantation—a retrospective outcome comparison
por: Steiner, Stefan, et al.
Publicado: (2021)

Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication
por: Li, Jun, et al.
Publicado: (2018)

nsPEF-induced PIP(2) depletion, PLC activity and actin cytoskeletal cortex remodeling are responsible for post-exposure cellular swelling and blebbing
por: Tolstykh, Gleb P., et al.
Publicado: (2016)

Characterization of exo-s, exo-u, and alg virulence factors and antimicrobial resistance in Pseudomonas aeruginosa isolated from migratory Egyptian vultures from India
por: Sharma, Pradeep, et al.
Publicado: (2014)

Ultrastructure of blebbing and phagocytosis of blebs by hyperplastic thyroid epithelial cells in vivo
Publicado: (1977)

Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine-4,5-dione
por: Kato, Yoji, et al.
Publicado: (2014)

Bioenergetics Failure and Oxidative Stress in Brain Stem Mediates Cardiovascular Collapse Associated with Fatal Methamphetamine Intoxication
por: Li, Faith C. H., et al.
Publicado: (2012)

Evaluation of filtering blebs using the ‘Wuerzburg bleb classification score’ compared to clinical findings
por: Furrer, Sandra, et al.
Publicado: (2012)

The relationship of bleb morphology and the outcome of needle revision with 5-fluorouracil in failing filtering bleb
por: Lee, Yung-Sung, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_20429rt9cgo9adl118lj9lfh07