Contribution of increased ISG15, ISGylation and deregulated Type I IFN signaling in Usp18 mutant mice during the course of bacterial infections

Host genetics plays a key role in susceptibility to Salmonella Typhimurium infection. We previously used N-ethyl-N-nitrosourea (ENU) mutagenesis to identify a loss of function mutation within the gene ubiquitin specific peptidase 18 (Usp18(Ity9)), which confers increased susceptibility to Salmonella...

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Detalles Bibliográficos
Autores principales: Dauphinee, Shauna M., Richer, Etienne, Eva, Megan M., McIntosh, Fiona, Paquet, Marilène, Dangoor, David, Burkart, Christoph, Zhang, Dong-Er, Gruenheid, Samantha, Gros, Philippe, Behr, Marcel, Malo, Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111656/
https://www.ncbi.nlm.nih.gov/pubmed/24807690
http://dx.doi.org/10.1038/gene.2014.17

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