The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

A fundamental question in neurobiology is how the balance between proliferation and differentiation of neuronal precursors is maintained to ensure that the proper number of brain neurons is generated. Substantial evidence implicates DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase...

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Detalles Bibliográficos
Autores principales: Soppa, Ulf, Schumacher, Julian, Florencio Ortiz, Victoria, Pasqualon, Tobias, Tejedor, Francisco J, Becker, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111700/
https://www.ncbi.nlm.nih.gov/pubmed/24806449
http://dx.doi.org/10.4161/cc.29104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111700/
https://www.ncbi.nlm.nih.gov/pubmed/24806449
http://dx.doi.org/10.4161/cc.29104

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