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The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation
A fundamental question in neurobiology is how the balance between proliferation and differentiation of neuronal precursors is maintained to ensure that the proper number of brain neurons is generated. Substantial evidence implicates DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase...
Autores principales: | Soppa, Ulf, Schumacher, Julian, Florencio Ortiz, Victoria, Pasqualon, Tobias, Tejedor, Francisco J, Becker, Walter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111700/ https://www.ncbi.nlm.nih.gov/pubmed/24806449 http://dx.doi.org/10.4161/cc.29104 |
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