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Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells
Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical man...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111871/ https://www.ncbi.nlm.nih.gov/pubmed/25089237 http://dx.doi.org/10.1007/s13659-014-0028-0 |
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author | Ma, Jun-Zeng Yang, Li-Xin Shen, Xiao-Ling Qin, Ji-Huan Deng, Li-Lan Ahmed, Selena Xu, Hong-Xi Xue, Da-Yuan Ye, Jiang-Xia Xu, Gang |
author_facet | Ma, Jun-Zeng Yang, Li-Xin Shen, Xiao-Ling Qin, Ji-Huan Deng, Li-Lan Ahmed, Selena Xu, Hong-Xi Xue, Da-Yuan Ye, Jiang-Xia Xu, Gang |
author_sort | Ma, Jun-Zeng |
collection | PubMed |
description | Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone (DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic. [Image: see text] |
format | Online Article Text |
id | pubmed-4111871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-41118712014-07-30 Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells Ma, Jun-Zeng Yang, Li-Xin Shen, Xiao-Ling Qin, Ji-Huan Deng, Li-Lan Ahmed, Selena Xu, Hong-Xi Xue, Da-Yuan Ye, Jiang-Xia Xu, Gang Nat Prod Bioprospect Original Article Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone (DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic. [Image: see text] Springer Berlin Heidelberg 2014-07-10 /pmc/articles/PMC4111871/ /pubmed/25089237 http://dx.doi.org/10.1007/s13659-014-0028-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Ma, Jun-Zeng Yang, Li-Xin Shen, Xiao-Ling Qin, Ji-Huan Deng, Li-Lan Ahmed, Selena Xu, Hong-Xi Xue, Da-Yuan Ye, Jiang-Xia Xu, Gang Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
title | Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
title_full | Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
title_fullStr | Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
title_full_unstemmed | Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
title_short | Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
title_sort | effects of traditional chinese medicinal plants on anti-insulin resistance bioactivity of dxms-induced insulin resistant hepg2 cells |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111871/ https://www.ncbi.nlm.nih.gov/pubmed/25089237 http://dx.doi.org/10.1007/s13659-014-0028-0 |
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