Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea

Three new humulane-type sesquiterpenes, antrodols A–C (1–3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A–C (1–3) are first examples of humulane-type sesquiterpenes isolated from c...

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Detalles Bibliográficos
Autores principales: Chen, Zi-Ming, Fan, Qiong-Ying, Yin, Xia, Yang, Xiao-Yan, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111878/
https://www.ncbi.nlm.nih.gov/pubmed/25089238
http://dx.doi.org/10.1007/s13659-014-0032-4
Descripción
Sumario:Three new humulane-type sesquiterpenes, antrodols A–C (1–3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A–C (1–3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A (1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases (PTPs): MEG2 and PTP1Bc. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0032-4) contains supplementary material, which is available to authorized users.

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