Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea

Three new humulane-type sesquiterpenes, antrodols A–C (1–3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A–C (1–3) are first examples of humulane-type sesquiterpenes isolated from c...

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Autores principales: Chen, Zi-Ming, Fan, Qiong-Ying, Yin, Xia, Yang, Xiao-Yan, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111878/
https://www.ncbi.nlm.nih.gov/pubmed/25089238
http://dx.doi.org/10.1007/s13659-014-0032-4
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author Chen, Zi-Ming
Fan, Qiong-Ying
Yin, Xia
Yang, Xiao-Yan
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
author_facet Chen, Zi-Ming
Fan, Qiong-Ying
Yin, Xia
Yang, Xiao-Yan
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
author_sort Chen, Zi-Ming
collection PubMed
description Three new humulane-type sesquiterpenes, antrodols A–C (1–3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A–C (1–3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A (1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases (PTPs): MEG2 and PTP1Bc. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0032-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-41118782014-07-30 Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea Chen, Zi-Ming Fan, Qiong-Ying Yin, Xia Yang, Xiao-Yan Li, Zheng-Hui Feng, Tao Liu, Ji-Kai Nat Prod Bioprospect Original Article Three new humulane-type sesquiterpenes, antrodols A–C (1–3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A–C (1–3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A (1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases (PTPs): MEG2 and PTP1Bc. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0032-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-07-17 /pmc/articles/PMC4111878/ /pubmed/25089238 http://dx.doi.org/10.1007/s13659-014-0032-4 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Chen, Zi-Ming
Fan, Qiong-Ying
Yin, Xia
Yang, Xiao-Yan
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea
title Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea
title_full Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea
title_fullStr Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea
title_full_unstemmed Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea
title_short Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea
title_sort three new humulane sesquiterpenes from cultures of the fungus antrodiella albocinnamomea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111878/
https://www.ncbi.nlm.nih.gov/pubmed/25089238
http://dx.doi.org/10.1007/s13659-014-0032-4
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