Lycopodine-Type Alkaloids from Lycopodium japonicum

Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodiumjaponicum Thunb. e...

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Detalles Bibliográficos
Autores principales: He, Juan, Wu, Xing-De, Liu, Fei, Liu, Yu-Cheng, Peng, Li-Yan, Zhao, Yu, Cheng, Xiao, Luo, Huai-Rong, Zhao, Qin-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111880/
https://www.ncbi.nlm.nih.gov/pubmed/25089239
http://dx.doi.org/10.1007/s13659-014-0027-1
Descripción
Sumario:Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodiumjaponicum Thunb. ex Murray (Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1–4 were evaluated for their acetylcholine esterase inhibitory activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0027-1) contains supplementary material, which is available to authorized users.

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