Lycopodine-Type Alkaloids from Lycopodium japonicum

Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodiumjaponicum Thunb. e...

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Detalles Bibliográficos
Autores principales: He, Juan, Wu, Xing-De, Liu, Fei, Liu, Yu-Cheng, Peng, Li-Yan, Zhao, Yu, Cheng, Xiao, Luo, Huai-Rong, Zhao, Qin-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111880/
https://www.ncbi.nlm.nih.gov/pubmed/25089239
http://dx.doi.org/10.1007/s13659-014-0027-1
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author He, Juan
Wu, Xing-De
Liu, Fei
Liu, Yu-Cheng
Peng, Li-Yan
Zhao, Yu
Cheng, Xiao
Luo, Huai-Rong
Zhao, Qin-Shi
author_facet He, Juan
Wu, Xing-De
Liu, Fei
Liu, Yu-Cheng
Peng, Li-Yan
Zhao, Yu
Cheng, Xiao
Luo, Huai-Rong
Zhao, Qin-Shi
author_sort He, Juan
collection PubMed
description Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodiumjaponicum Thunb. ex Murray (Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1–4 were evaluated for their acetylcholine esterase inhibitory activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0027-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-41118802014-07-30 Lycopodine-Type Alkaloids from Lycopodium japonicum He, Juan Wu, Xing-De Liu, Fei Liu, Yu-Cheng Peng, Li-Yan Zhao, Yu Cheng, Xiao Luo, Huai-Rong Zhao, Qin-Shi Nat Prod Bioprospect Original Article Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodiumjaponicum Thunb. ex Murray (Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1–4 were evaluated for their acetylcholine esterase inhibitory activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0027-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-07-17 /pmc/articles/PMC4111880/ /pubmed/25089239 http://dx.doi.org/10.1007/s13659-014-0027-1 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
He, Juan
Wu, Xing-De
Liu, Fei
Liu, Yu-Cheng
Peng, Li-Yan
Zhao, Yu
Cheng, Xiao
Luo, Huai-Rong
Zhao, Qin-Shi
Lycopodine-Type Alkaloids from Lycopodium japonicum
title Lycopodine-Type Alkaloids from Lycopodium japonicum
title_full Lycopodine-Type Alkaloids from Lycopodium japonicum
title_fullStr Lycopodine-Type Alkaloids from Lycopodium japonicum
title_full_unstemmed Lycopodine-Type Alkaloids from Lycopodium japonicum
title_short Lycopodine-Type Alkaloids from Lycopodium japonicum
title_sort lycopodine-type alkaloids from lycopodium japonicum
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111880/
https://www.ncbi.nlm.nih.gov/pubmed/25089239
http://dx.doi.org/10.1007/s13659-014-0027-1
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