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Administration of supplemental L-tyrosine with phenelzine: a clinical literature review

The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil(®)) prescribing information notes: “The potentiation of sympathomimetic substances and related compounds by MAO inhibitors may result in hypertensive crises (...

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Detalles Bibliográficos
Autores principales: Hinz, Marty, Stein, Alvin, Cole, Ted, Ryan, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112771/
https://www.ncbi.nlm.nih.gov/pubmed/25092999
http://dx.doi.org/10.2147/CPAA.S67271
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author Hinz, Marty
Stein, Alvin
Cole, Ted
Ryan, Patricia
author_facet Hinz, Marty
Stein, Alvin
Cole, Ted
Ryan, Patricia
author_sort Hinz, Marty
collection PubMed
description The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil(®)) prescribing information notes: “The potentiation of sympathomimetic substances and related compounds by MAO inhibitors may result in hypertensive crises (see WARNINGS). Therefore, patients being treated with NARDIL should not take […] L-tyrosine […]”. Interest in the scientific foundation of this claim was generated during routine patient care. A comprehensive literature search of Google Scholar and PubMed revealed no reported cases of hypertensive crisis associated with concomitant administration of L-tyrosine and phenelzine. Review of current US Food and Drug Administration nutritional guidelines relating to ongoing phenelzine studies reveals no mention and requires no consideration of L-tyrosine ingestion in combination with phenelzine. This paper is intended to provide an objective review of the science to then allow the reader to formulate the final opinion.
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spelling pubmed-41127712014-08-04 Administration of supplemental L-tyrosine with phenelzine: a clinical literature review Hinz, Marty Stein, Alvin Cole, Ted Ryan, Patricia Clin Pharmacol Review The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil(®)) prescribing information notes: “The potentiation of sympathomimetic substances and related compounds by MAO inhibitors may result in hypertensive crises (see WARNINGS). Therefore, patients being treated with NARDIL should not take […] L-tyrosine […]”. Interest in the scientific foundation of this claim was generated during routine patient care. A comprehensive literature search of Google Scholar and PubMed revealed no reported cases of hypertensive crisis associated with concomitant administration of L-tyrosine and phenelzine. Review of current US Food and Drug Administration nutritional guidelines relating to ongoing phenelzine studies reveals no mention and requires no consideration of L-tyrosine ingestion in combination with phenelzine. This paper is intended to provide an objective review of the science to then allow the reader to formulate the final opinion. Dove Medical Press 2014-07-22 /pmc/articles/PMC4112771/ /pubmed/25092999 http://dx.doi.org/10.2147/CPAA.S67271 Text en © 2014 Hinz et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Hinz, Marty
Stein, Alvin
Cole, Ted
Ryan, Patricia
Administration of supplemental L-tyrosine with phenelzine: a clinical literature review
title Administration of supplemental L-tyrosine with phenelzine: a clinical literature review
title_full Administration of supplemental L-tyrosine with phenelzine: a clinical literature review
title_fullStr Administration of supplemental L-tyrosine with phenelzine: a clinical literature review
title_full_unstemmed Administration of supplemental L-tyrosine with phenelzine: a clinical literature review
title_short Administration of supplemental L-tyrosine with phenelzine: a clinical literature review
title_sort administration of supplemental l-tyrosine with phenelzine: a clinical literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112771/
https://www.ncbi.nlm.nih.gov/pubmed/25092999
http://dx.doi.org/10.2147/CPAA.S67271
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