Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling

BACKGROUND: Acute lung injury (ALI) is associated with high mortality due to the lack of effective therapeutic strategies. Mechanical ventilation itself can cause ventilator-induced lung injury. Pulmonary vascular barrier function, regulated in part by Src kinase-dependent phosphorylation of caveoli...

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Detalles Bibliográficos
Autores principales: Piegeler, Tobias, Dull, Randal O, Hu, Guochang, Castellon, Maricela, Chignalia, Andreia Z, Koshy, Ruben G, Votta-Velis, E Gina, Borgeat, Alain, Schwartz, David E, Beck-Schimmer, Beatrice, Minshall, Richard D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112848/
https://www.ncbi.nlm.nih.gov/pubmed/25097454
http://dx.doi.org/10.1186/1471-2253-14-57

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